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Fig. 3 | Respiratory Research

Fig. 3

From: Cell-specific toxicity of short-term JUUL aerosol exposure to human bronchial epithelial cells and murine macrophages exposed at the air–liquid interface

Fig. 3

Short-term ALI JUUL aerosol exposure alters extracellular ROS and NO production in RAW 246.7 macrophages. JUUL crème brûlée-flavored aerosol exposure alters (a) cellular morphology as indicated by SEM analysis. Images were taken at 10,000× and 15,000× magnification. b JUUL crème brûlée-flavored aerosol exposure caused no effect in cellular viability (n = 3 per group); and c LDH release in the basal media (n = 3 per group); but significantly d increased extracellular ROS production (n = 3 per group); and e significantly decreased extacellular NO species production in murine macrophages compared to air controls (n = 3 per group). The Student’s t-test was used to compare results between JUUL aerosol-exposed and air controls. Data represent the mean ± SEM, *p < 0.05. Data represent a representative experiment (from three independent experiments) each performed in triplicate (n = 3 per group). See Additional file 1: Figures S3, S4 for the results of the other independent experiments

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Respiratory Research

ISSN: 1465-993X

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