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Fig. 5 | Respiratory Research

Fig. 5

From: Dexamethasone rescues TGF-β1-mediated β2-adrenergic receptor dysfunction and attenuates phosphodiesterase 4D expression in human airway smooth muscle cells

Fig. 5

DEX inhibits TGF-β1-induced pde4d expression in HASM. HASM were pretreated with DEX (1–100 nM, 30 min) prior to stimulation with TGF-β1 (10 ng/ml, 18 h). mRNA was extracted, reverse transcribed, and assessed for pde4d and β-actin expression by TaqMan qPCR analysis. Data is represented as % of pde4d expression induced by TGF-β1, with pde4d expression normalized to β-actin. Data is representative of n = 4–6 separate cell lines as mean ± SEM, *p < 0.05 using a one-way ANOVA, and comparisons between two conditions assessed by Student’s t-test. TGF-β1 vs TGF-β1+ DEX (30 nM), p = 0.08

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Respiratory Research

ISSN: 1465-993X

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