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Fig. 4 | Respiratory Research

Fig. 4

From: Dexamethasone rescues TGF-β1-mediated β2-adrenergic receptor dysfunction and attenuates phosphodiesterase 4D expression in human airway smooth muscle cells

Fig. 4

Dexamethasone (DEX) rescues TGF-β1-mediated attenuation of ISO- and CTX-induced cAMP production in HASM. HASM were pretreated with (a, b) DEX (10–100 nM, 30 min) prior to TGF-β1 (10 ng/ml, 18 h) stimulation. HASM were subsequently stimulated with (a) ISO (1 μM, 5 min) or (b) CTX (0.25 μg/ml, 45 min) and assessed for cAMP generation. Data is expressed % of max cAMP produced either by ISO (a) or CTX (b). Data is representative of (a) n = 6–13 (b) or n = 4–8 separate cell lines as mean ± SEM, *p < 0.05 comparing control/ISO/CTX to TGF-β1/ISO/CTX, and TGF-β1/ISO/CTX to TGF-β1/ISO/CTX ± DEX using a one-way ANOVA, and comparisons between two conditions assessed by Student’s t-test

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Respiratory Research

ISSN: 1465-993X

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