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Fig. 1 | Respiratory Research

Fig. 1

From: Dexamethasone rescues TGF-β1-mediated β2-adrenergic receptor dysfunction and attenuates phosphodiesterase 4D expression in human airway smooth muscle cells

Fig. 1

Cholera toxin (CTX) increases cAMP levels in HASM, which is blunted by overnight treatment with TGF-β1. A time course of CTX-, a Gαs activator, induced cAMP production in HASM (0.25 μg/ml, 0–75 min) was performed in the presence and absence of TGF-β1 (10 ng/ml, 18 h). Data is expressed fold change over vehicle control as mean ± SEM for n = 3 separate cell lines, three additional donors were added to the 45 min to confirm appropriate time point. *p < 0.05 as assessed by one-way ANOVA, and comparisons between two conditions assessed by Student’s t-test

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