Fig. 1
Expression of ACE2, TMPRSS2, BSG and FURIN in respiratory epithelium of smokers, asthmatics and healthy individuals. a-d Microarray datasets of bronchial brushings from healthy non-smokers and smokers. GSE17905: non-smokers small airways (n = 41), large airways (n = 21); smokers small airways (n = 52), large airways (n = 31). GSE63127: non-smokers (n = 87); smokers (n = 143). Gene expression for a ACE2, b TMPRSS2, c BSG, and d FURIN. e-h Microarray datasets of airway epithelial brushings from healthy controls (GSE41861, bronchial n = 30 and nasal n = 17; GSE64913, central airway n = 20 and peripheral airway n = 17; GSE4302, n = 28; GSE67472, n = 43) and asthma patients (GSE41861, bronchial n = 51 and nasal n = 40; GSE64913, central airway n = 11 and peripheral airway n = 11; GSE4302, n = 42; GSE67472, n = 62). Gene expression for e ACE2, f TMPRSS2, g BSG, and h FURIN. Data are shown as log2 transformed expression values not corrected for proband age and sex. Multiple comparison significance levels: *p < 0.002