Regulation of ATP binding cassette transporter A1 (ABCA1) expression: cholesterol-dependent and – independent signaling pathways with relevance to inflammatory lung disease

Table 1 Currently known effects of clinical and experimental drugs on ABCA1 expression in cells in vitro

Cell Type	Stimuli	Change in ABCA1 Protein Expression	References
Macrophage Cells	Simvastatin Atorvastatin TNF Cholesterol/CD Oxysterol (25 Hydroxyl Cholesterol) Cigarette Smoke Extract	↓ ↓ ↓/↑ ↑ ↑ ↓	[37, 38] [37, 38] [16, 39] [40] [41] [12]
Bronchial Epithelial Cells	Simvastatin Atorvastatin TNF Cholesterol/CD Oxysterol (25 Hydroxyl Cholesterol)	ns ns ↑ ↑ ↑	[4] [4] [4] [4] [4]
Airway Smooth Muscle Cells	Cholesterol/CD	↑	[42]

ISSN: 1465-993X