Long-term exposure to PM10 and NO2 in relation to lung function and imaging phenotypes in a COPD cohort

Kwon, Sung Ok; Hong, Seok Ho; Han, Young-Ji; Bak, So Hyeon; Kim, Junghyun; Lee, Mi Kyeong; London, Stephanie J.; Kim, Woo Jin; Kim, Sun-Young

doi:10.1186/s12931-020-01514-w

Respiratory Research

Table 6 Effect estimates and 95% confidence intervals of FVC and FEV₁, emphysema index, and mean wall area % for interquartile range increases in PM₁₀ (4.4 μg/m³) and NO₂ (3.0 ppb) by gender in the CODA cohort

From: Long-term exposure to PM₁₀ and NO₂ in relation to lung function and imaging phenotypes in a COPD cohort

	PM₁₀				P for interaction	NO₂				P for interaction
	Male (n = 335)		Female (n = 122)			Male (n = 335)		Female (n = 122)
	β (95% CI)	P	β (95% CI)	P		β (95% CI)	P	β (95% CI)	P
FVC, L
Model 1^a	−0.20 (−0.30, − 0.10)	0.000	0.02 (− 0.14, 0.19)	0.762	0.021	−0.11 (− 0.20, − 0.02)	0.023	−0.03 (− 0.18, 0.12)	0.704	0.365
Model 2^b	−0.19 (− 0.30, − 0.08)	0.001	0.03 (− 0.13, 0.19)	0.727	0.022	−0.12 (− 0.21, − 0.02)	0.015	−0.05 (− 0.20, 0.10)	0.527	0.436
Model 3^c	−0.18 (− 0.29, − 0.07)	0.001	0.03 (− 0.13, 0.20)	0.697	0.024	−0.11 (− 0.20, − 0.02)	0.022	−0.04 (− 0.19, 0.11)	0.608	0.430
FEV₁, L
Model 1^a	−0.07 (− 0.15, 0.01)	0.080	0.05 (− 0.08, 0.18)	0.423	0.103	−0.01 (− 0.08, 0.07)	0.856	0.03 (− 0.08, 0.15)	0.556	0.546
Model 2^b	−0.05 (− 0.14, 0.03)	0.236	0.06 (− 0.06, 0.19)	0.325	0.122	−0.01 (− 0.08, 0.06)	0.756	0.02 (− 0.09, 0.14)	0.695	0.613
Model 3^c	−0.09 (− 0.17, − 0.01)	0.034	0.00 (− 0.13, 0.12)	0.945	0.231	−0.01 (− 0.08, 0.06)	0.833	−0.02 (− 0.13, 0.09)	0.764	0.885
Emphysema index
Model 1^a	1.15 (0.14, 2.17)	0.026	1.08 (−0.64, 2.80)	0.219	0.942	0.42 (−0.54, 1.37)	0.391	0.15 (−1.50, 1.84)	0.861	0.786
Model 2^b	1.09 (−0.21, 2.40)	0.100	1.04 (−0.77, 2.85)	0.261	0.957	0.43 (−0.52, 1.38)	0.374	0.08 (−1.60, 1.77)	0.922	0.723
Model 3^c	0.95 (−0.31, 2.21)	0.139	1.54 (−0.22, 3.31)	0.086	0.549	0.26 (−0.67, 1.18)	0.586	0.29 (−1.30, 1.93)	0.724	0.968
Mean wall area %
Model 1^a	1.30 (0.42, 2.18)	0.004	0.25 (−1.20, 1.74)	0.744	0.227	0.19 (−0.64, 1.01)	0.657	0.98 (−0.49, 2.45)	0.190	0.352
Model 2^b	0.86 (−0.27, 1.98)	0.135	−0.06 (−1.60, 1.51)	0.945	0.300	0.21 (−0.62, 1.03)	0.624	0.89 (−0.57, 2.34)	0.231	0.418
Model 3^c	0.67 (−0.43, 1.77)	0.234	0.15 (−1.40, 1.69)	0.846	0.550	0.11 (−0.69, 0.91)	0.784	0.98 (−0.44, 2.40)	0.177	0.295

^aModel 1 was adjusted for age, education, height, weight, smoking, pack-years, medication use, and job
^bModel 2 was adjusted for age, education, height, weight, smoking, pack-years, medication use, job and calendar year at PFT test
^cModel 3 was adjusted for age, education, height, weight, smoking, pack-years, medication use, job, calendar year at PFT test, asthma and COPD

Back to article page

ISSN: 1465-993X

Contact us

General enquiries: journalsubmissions@springernature.com