Long-term exposure to PM10 and NO2 in relation to lung function and imaging phenotypes in a COPD cohort

Kwon, Sung Ok; Hong, Seok Ho; Han, Young-Ji; Bak, So Hyeon; Kim, Junghyun; Lee, Mi Kyeong; London, Stephanie J.; Kim, Woo Jin; Kim, Sun-Young

doi:10.1186/s12931-020-01514-w

Respiratory Research

Table 5 Effect estimates and 95% confidence intervals of FVC, FEV₁, emphysema index, and mean wall area % for interquartile range increases in PM₁₀ (4.4 μg/m³) and NO₂ (3.0 ppb) according to smoking status in the CODA cohort

From: Long-term exposure to PM₁₀ and NO₂ in relation to lung function and imaging phenotypes in a COPD cohort

	PM₁₀				P for interaction	NO₂				P for interaction
	Never smoker (n = 165)		Ever (former/current) smoker (n = 292)			Never smoker (n = 165)		Ever (former/current) smoker (n = 292)
	β (95% CI)	P	β (95% CI)	P		β (95% CI)	P	β (95% CI)	P
FVC, L
Model 1^a	0.02 (−0.13, 0.16)	0.818	− 0.21 (− 0.32, − 0.10)	0.000	0.011	−0.05 (− 0.18, 0.07)	0.410	−0.11 (− 0.21, − 0.01)	0.038	0.510
Model 2^b	0.02 (− 0.12, 0.17)	0.760	− 0.20 (− 0.32, − 0.09)	0.001	0.012	−0.07 (− 0.20, 0.05)	0.264	− 0.11 (− 0.21, − 0.01)	0.028	0.626
Model 3^c	0.03 (− 0.12, 0.18)	0.683	− 0.20 (− 0.31, − 0.08)	0.001	0.010	− 0.07 (− 0.20, 0.06)	0.279	− 0.10 (− 0.20, 0.00)	0.049	0.708
FEV₁, L
Model 1^a	0.04 (− 0.07, 0.16)	0.432	− 0.09 (− 0.17, 0.00)	0.046	0.064	0.00 (− 0.10, 0.10)	0.965	0.01 (− 0.07, 0.09)	0.825	0.861
Model 2^b	0.06 (− 0.05, 0.18)	0.302	−0.07 (− 0.16, 0.02)	0.151	0.071	− 0.01 (− 0.12, 0.09)	0.770	0.01 (− 0.07, 0.08)	0.898	0.751
Model 3^c	0.00 (−0.11, 0.11)	0.967	−0.10 (− 0.19, − 0.02)	0.020	0.133	−0.04 (− 0.14, 0.05)	0.408	0.01 (− 0.07, 0.08)	0.843	0.429
Emphysema index
Model 1^a	1.16 (−0.37, 2.68)	0.136	0.89 (− 0.18, 1.96)	0.103	0.773	0.20 (−1.20, 1.62)	0.781	0.42 (−0.61, 1.45)	0.421	0.800
Model 2^b	1.08 (−0.57, 2.73)	0.200	0.79 (−0.56, 2.14)	0.252	0.755	0.19 (−1.20, 1.60)	0.794	0.42 (− 0.61, 1.45)	0.421	0.790
Model 3^c	1.45 (−0.16, 3.06)	0.077	0.67 (−0.64, 1.98)	0.318	0.388	0.28 (−1.10, 1.65)	0.686	0.24 (−0.75, 1.24)	0.631	0.964
Mean wall area %
Model 1^a	0.75 (−0.55, 2.06)	0.257	1.20 (0.28, 2.11)	0.011	0.577	1.16 (− 0.05, 2.37)	0.061	−0.02 (− 0.90, 0.85)	0.956	0.114
Model 2^b	0.39 (− 1.00, 1.80)	0.587	0.73 (−0.42, 1.88)	0.215	0.755	1.14 (−0.06, 2.34)	0.063	−0.03 (− 0.90, 0.84)	0.952	0.116
Model 3^c	0.52 (−0.86, 1.90)	0.459	0.53 (−0.60, 1.65)	0.360	0.996	1.14 (−0.03, 2.31)	0.057	−0.10 (− 0.95, 0.75)	0.810	0.088

^aModel 1 was adjusted for age, gender, education, height, weight, pack-years, medication use, and job
^bModel 2 was adjusted for age, gender, education, height, weight, pack-years, medication use, job and calendar year at PFT test
^cModel 3 was adjusted for age, gender, education, height, weight, pack-years, medication use, job, calendar year at PFT test, asthma and COPD

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