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Table 4 Effect estimates and 95% confidence intervals of FVC, FEV1, emphysema index, and mean wall area % for interquartile range increases in PM10 (4.4 μg/m3) and NO2 (3.0 ppb) according to COPD status in the CODA cohort

From: Long-term exposure to PM10 and NO2 in relation to lung function and imaging phenotypes in a COPD cohort

 

PM10

P for interaction

NO2

P for interaction

Non-COPD (n = 161)

COPD (n = 296)

Non-COPD (n = 161)

COPD (n = 296)

β (95% CI)

P

β (95% CI)

P

β (95% CI)

P

β (95% CI)

P

FVC, L

 Model 1a

−0.12 (−0.26, 0.03)

0.117

−0.13 (− 0.24, − 0.02)

0.018

0.900

−0.12 (− 0.25, 0.01)

0.071

−0.06 (− 0.15, 0.04)

0.261

0.436

 Model 2b

−0.09 (− 0.25, 0.06)

0.226

− 0.11 (− 0.22, 0.00)

0.060

0.875

−0.15 (− 0.28, −.02)

0.024

−0.06 (− 0.16, 0.04)

0.231

0.256

 Model 3c

−0.11 (− 0.26, 0.04)

0.161

− 0.13 (− 0.24, − 0.01)

0.032

0.865

− 0.15 (− 0.28, −.02)

0.023

−0.05 (− 0.15, 0.04)

0.268

0.229

FEV1, L

 Model 1a

− 0.09 (− 0.20, 0.02)

0.112

− 0.04 (− 0.12, 0.04)

0.359

0.451

−0.03 (− 0.13, 0.06)

0.515

0.00 (− 0.07, 0.08)

0.912

0.550

 Model 2b

−0.09 (− 0.20, 0.03)

0.128

− 0.04 (− 0.12, 0.05)

0.387

0.452

−0.04 (− 0.14, 0.06)

0.419

0.00 (− 0.07, 0.08)

0.930

0.474

 Model 3c

−0.10 (− 0.21, 0.02)

0.091

− 0.05 (− 0.13, 0.04)

0.270

0.456

−0.04 (− 0.14, 0.06)

0.413

0.01 (− 0.07, 0.08)

0.861

0.437

Emphysema index

 Model 1a

0.65 (−0.89, 2.19)

0.405

1.55 (0.52, 2.57)

0.003

0.337

−0.09 (−1.60, 1.38)

0.908

0.47 (− 0.48, 1.42)

0.332

0.523

 Model 2b

0.24 (−1.50, 1.99)

0.789

1.21 (− 0.02, 2.44)

0.053

0.298

−0.23 (−1.70, 1.23)

0.756

0.51 (−0.43, 1.46)

0.288

0.392

 Model 3c

0.41 (−1.30, 2.15)

0.641

1.39 (0.17, 2.62)

0.026

0.291

−0.22 (− 1.70, 1.23)

0.764

0.46 (− 0.48, 1.40)

0.337

0.429

Mean wall area %

 Model 1a

2.33 (1.00, 3.66)

0.001

0.64 (−0.25, 1.53)

0.159

0.037

0.33 (−0.95, 1.61)

0.614

0.34 (− 0.49, 1.17)

0.417

0.985

 Model 2b

1.61 (0.10, 3.12)

0.037

0.05 (−1.00, 1.11)

0.922

0.055

0.16 (− 1.10, 1.42)

0.809

0.39 (−0.43, 1.21)

0.346

0.751

 Model 3c

1.65 (0.13, 3.16)

0.033

0.09 (−0.97, 1.16)

0.862

0.055

0.16 (−1.10, 1.42)

0.807

0.38 (− 0.44, 1.20)

0.360

0.764

  1. aModel 1 was adjusted for age, gender, education, height, weight, smoking, pack-years, medication use, and job
  2. bModel 2 was adjusted for age, gender, education, height, weight, smoking, pack-years, medication use, job and calendar year at PFT test
  3. cModel 3 was adjusted for age, gender, education, height, weight, smoking, pack-years, medication use, job, calendar year at PFT test, and asthma