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Table 3 Effect estimates and 95% confidence intervals of FVC, FEV1, emphysema index, and mean wall area % for interquartile range increases in PM10 (4.4 μg/m3) and NO2 (3.0 ppb) in the CODA cohort

From: Long-term exposure to PM10 and NO2 in relation to lung function and imaging phenotypes in a COPD cohort

 

All (n = 457)

PM10

NO2

β (95% CI)

P

β (95% CI)

P

FVC, L

 Model 1a

−0.13 (− 0.22, − 0.05)

0.003

− 0.09 (− 0.17, − 0.01)

0.035

 Model 2b

− 0.13 (− 0.22, − 0.03)

0.011

− 0.10 (− 0.18, − 0.02)

0.017

 Model 3c

− 0.12 (− 0.22, − 0.02)

0.015

− 0.09 (− 0.17, − 0.01)

0.029

FEV1, L

 Model 1a

− 0.04 (− 0.11, 0.03)

0.294

0.00 (− 0.06, 0.07)

0.881

 Model 2b

− 0.02 (− 0.09, 0.06)

0.647

0.00 (− 0.07, 0.06)

0.950

 Model 3c

−0.07 (− 0.14, 0.01)

0.078

− 0.01 (− 0.07, 0.05)

0.741

Emphysema index

 Model 1a

1.13 (0.25, 2.02)

0.012

0.35 (−0.48, 1.19)

0.406

 Model 2b

1.08 (−0.08, 2.23)

0.068

0.35 (−0.49, 1.18)

0.412

 Model 3c

1.13 (0.01, 2.25)

0.048

0.26 (−0.54, 1.07)

0.519

Mean wall area %

 Model 1a

1.04 (0.27, 1.80)

0.008

0.37 (−0.35, 1.10)

0.311

 Model 2b

0.58 (−0.42, 1.58)

0.253

0.37 (−0.35, 1.09)

0.317

 Model 3c

0.51 (−0.46, 1.49)

0.302

0.32 (−0.38, 1.02)

0.373

  1. aModel 1 was adjusted for age, gender, education, height, weight, smoking, pack-years, medication use, and job
  2. bModel 2 was adjusted for age, gender, education, height, weight, smoking, pack-years, medication use, job and calendar year at PFT test
  3. cModel 3 was adjusted for age, gender, education, height, weight, smoking, pack-years, medication use, job, calendar year at PFT test, asthma and COPD
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Respiratory Research

ISSN: 1465-993X

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