Inflammatory phenotyping predicts clinical outcome in COVID-19

Respiratory Research

Table 3 Associations between cytokine levels and poor outcome in COVID-19 in patients under 70 years old (N = 66)

	OR (95% CI) for composite end point^c	Adjusted^b OR (95% CI) for composite end point^c	AUROC for Adjusted model^b
Model with demographics +NEWS2 only			0.77 (0.64, 0.87)
Model with COVID-19 blood panel^d			0.88 (0.74, 0.97)
IL-6	1.01 (0.99, 1.02)	1.01 (0.99, 1.02)	0.79 (0.65, 0.88)
TNF	1.12 (1.03, 1.22)	1.17 (1.03, 1.35)	0.84 (0.73, 0.92)
IL-8	1.02 (1.00, 1.05)	1.01 (0.98, 1.03)	0.78 (0.66, 0.89)
IL-1β	9.20 (0.97, 87.40)	19.75 (0.78, 497.78)	0.82 (0.70, 0.92)
GM-CSF	0.96 (0.84, 1.10)	0.93 (0.78, 1.11)	0.77 (0.63, 0.87)
IFN-γ	0.99 (0.98, 1.01)	1.00 (0.98, 1.03)	0.77 (0.64, 0.88)
IL-33	13.03 (2.03, 83.72)	11.14 (1.01, 123.72)	0.83 (0.72, 0.91)
IL-10	1.01 (0.99, 1.02)	1.00 (0.98, 1.02)	0.77 (0.64, 0.87)
Model with all cytokines^a included			0.92 (0.83, 0.97)

Significant results (AUROC> 0.8) in bold
^aAll cytokine values have been standardised before including in the model
^bAdjusted models control for gender, age, NEWS2 Score, comorbid conditions and smoking status
^cComposite end point was admission to the intensive care, the use mechanical ventilation, and/or death
^dCOVID-19 blood panel comprised neutrophils, lymphocytes, neutrophil:lymphocyte ratio, C-reactive protein, Lactate Dehydrogenase, D dimer, Ferritin and high sensitivity cardiac troponin I

ISSN: 1465-993X