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Table 3 Adaptive servo-ventilation settings for the OTRLASV population based on k-means clusters

From: Patterns of adaptive servo-ventilation settings in a real-life multicenter study: pay attention to volume!

 

Total

n = 177 (100%)

Cluster 1

n = 53 (29.9%)

Cluster 2

n = 58 (32.7%)

Cluster 3

n = 33 (18.6%)

Cluster 4

n = 20 (11.3%)

Cluster 5

n = 13 (7.3%)

P

Fixed EPAPk (cmH2O)

n = 121

n = 39

n = 46

n = 12

n = 15

n = 9

 

6.00

8.00 e, i

5.00 b, e, j,

6.50 j

8.00 b, d

5.00 d, i

< 0.001

[5.00–9.00]

[5.00–10.00]

[4.00–6.00]

[5.00–9.00]

[6.00–12.00]

[5.00–6.00]

 

(4.00–14.00)

(4.00–14.00)

(4.00–13.00)

(4.00–12.00)

(4.00–14.00)

(4.00–7.00)

 

Auto-EPAP (cmH2O)k

n = 56

n = 14

n = 12

n = 21

n = 5

n = 4

 

EPAPmin

4.00

4.50

4.00

4.00

4.00

5.00

0.529

[4.00–5.50]

[4.00–6.00]

[4.00–4.50]

[4.00–6.00]

[4.00–5.00]

[4.50–6.50]

 

(4.00–13.00)

(4.00–13.00)

(4.00–7.00)

(4.00–10.00)

(4.00–8.00)

(4.00–8.00)

 

EPAPmax

10

10

10

10

9

7

0.211

[8.00–12.00]

[8.00–12.00]

[8.00–10.00]

[9.00–12.00]

[8.00–10.00]

[6.00–9.50]

 

(3.00–18.00)

(3.00–15.00)

(5.00–10.00)

(5.00–18.00)

(8.00–12.00)

(5.00–12.00)

 

IPS (cmH2O)k

n = 176

n = 53

n = 57

n = 33

n = 20

n = 13

 

IPSmin

3.00

3.00 e

3.00 e, j

0.00 j

3.00

3.00

< 0.001

[0.00–3.00]

[3.00–3.00]

[3.00–6.50]

[0.00–3.00]

[0.00–3.00]

[3.00–4.00]

 

(0.00–15.00)

(0.00–7.5.00)

(0.00–15.00)

(0.00–8.00)

(0.00–10.00)

(0.00–10.00)

 

IPSmax

10

10

10

10

10

10

0.063

[9.00–10.00]

[10.00–10.00]

[10.00–12.00]

[10.00–11.00]

[8.00–10.00]

[8.00–10.00]

 

(3.00–20.00)

(5.00–15.00)

(3.00–20.00)

(5.00–15.00)

(5.00–15.00)

(5.00–13.00)

 

Pmax (cmH2O)k

n = 129

n = 42

n = 37

n = 28

n = 15

n = 7

 

19

19

19

20.00

18.00

17.00

0.912

[16.00–21.00]

[17.00–21.00]

[15.00–22.00]

[15.00–23.50]

[15.00–20.00]

[13.00–20.00]

 

(11.00–25.00)

(12.00–25.00)

(12.00–25.00)

(11.00–25.00)

(14.00–25.00)

(12.00–25.00)

 

Fixed backup RRk (cycle/min)

n = 39

n = 5

n = 25

n = 3

n = 2

n = 4

 

12

12

11.5

11.5

11.5

11.5

0.856

[11.00–12.00]

[12.00–12.00]

[10.00–12.50]

[10.00–12.00]

[10.00–12.00]

[10.00–12.00]

 

(8.00–16.00)

(8.00–14.00)

(10.00–16.00)

(10.00–22.00)

(10.00–22.00)

(10.00–22.00)

 

Auto backup RRk

n = 174

n = 52

n = 57

n = 33

n = 20

n = 12

 

135 (77.59%)

47(90.38%) e

32 (56.14%) e, j

30 (90.91%) j

18 (90.00%)

8 (66.67%)

< 0.001

Slope levell

n = 42

n = 5

n = 26

n = 3

n = 3

n = 5

 

2

2

2

1

3

3

0.146

[2.00–3.00]

[1.00–2.00]

[2.00–3.00]

[1.00–2.00]

[2.00–3.00]

[2.00–3.00]

 

(1.00–6.00)

(1.00–3.00)

(1.00–6.00)

(1.00–2.00)

(2.00–3.00)

(2.00–3.00)

 

Ti minl (second)

n = 38

n = 5

n = 24

n = 3

n = 2

n = 4

 

1.65

1.60

1.70

1.50

1.45

1.60

0.736

[1.40–1.80]

[1.40–1.80]

[1.40–1.90]

[1.00–1.60]

[1.20–1.70]

[1.35–1.85]

 

(1.00–2.20)

(1.00–2.10)

(1.00–2.20)

(1.00–1.60)

(1.20–1.70)

(1.20–2.00)

 

Interface

n = 177

n = 53

n = 58

n = 33

n = 20

n = 135

 

Oronasal

89 (50.28%)

29 (54.72%)

27 (46.55%)

16 (48.48%)

12 (60.00%)

(38.46%)

0.687

Nasal

81 (45.76%)

23 (43.40%)

29 (50.00%)

15 (45.45%)

6 (30.00%)

8 (61.54%)

0.427

Nasal Pillows

9 (5.08%)

1 (1.89%)

4 (6.9%)

2 (6.06%)

2 (10%)

0 (0.00%)

0.492

Heated humidifier

n = 177

n = 53

n = 58

n = 33

n = 20

n = 13

 

127 (71.75)

43 (81.13)

34 (58.62)

26 (78.79)

15 (75.00)

9 (69.23)

0.092

Heated breathing tube

n = 177

n = 53

n = 58

n = 33

n = 20

n = 13

 

47 (26.55)

14 (26.42) f

8 (13.79) j

19 (57.58) f, j, h

5 (25.00)

1 (7.69) h

< 0.001

  1. Quantitative variables were summarized using medians, [IQ25–75] and (min – max), while categories were described by numbers and (%). The total percentage for interfaces is > 100% because multiple interfaces were used by 2 patients
  2. Significant (p < 0.05) post-hoc pairwise comparisons after Holm correction (within lines) were presented using labels a, b, c, d, e, f, g, h, I, j. Label a indicates a significant difference between Cluster 1 and Cluster 4, label b indicates a significant difference between Cluster 2 and Cluster 4, label c indicates a significant difference between Cluster 3 and Cluster 4, label d indicates a significant difference between Cluster 4 and Cluster 5, label e indicates a significant difference between Cluster 1 and Cluster 2, label f indicates a significant difference between Cluster 1 and Cluster 3, label g indicates a significant difference between Cluster 2 and Cluster 5, label h indicates a significant difference between Cluster 3 and Cluster 5, label i indicates a significant difference between Cluster 1 and Cluster 5, label j indicates a significant difference between Cluster 2 and Cluster 3
  3. CSA Central sleep apnea, EPAP Expiratory positive airway pressure, IPS Inspiratory pressure support, max maximum, min minimum, OSA Obstructive sleep apnea, Pmax maximum pressure, RR Respiratory rate, TECSA Treatment emergent central sleep apnea, Ti min inspiratory support minimum pressurization time
  4. kFor ASV-setting variables shared by both manufacturers, the data were pooled (EPAP (fixed or minimum/maximum); IPS (minimum and maximum), Pmax, RR or auto RR). lFor slope level and minimum inspiratory time, the data concern only Philips Respironics devices
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Respiratory Research

ISSN: 1465-993X

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