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Table 1 Characteristics of each trial included in meta-analysis

From: The effects of anti-inflammatory agents as host-directed adjunct treatment of tuberculosis in humans: a systematic review and meta-analysis

Author (year)

Study setting (s)

Trial registration

Anti-TB therapy

Type, dose and route of treatment (intervention)

Martineau 2011 [21]

UK

NCT00419068

2 months HRZE

Vit D3, 2.5 mg,oral

Daley 2015 [16]

India

NCT00366470

2 months HRZE

Vit D3, 2.5 mg,oral

Farazi 2017 [36]

Iran

IRCT201407029855N5

2 months HRZE then 4 months RH

Vit D3,11.2 mg,intramuscular

Mily 2015 [18]

Bangladesh

NCT01580007

2 months HRZE then 4 months RH

Vit D3,0.13 mg and PBA,500 mg,oral

Nursyam 2006 [37]

Indonesia

NM

2 months HRZE then 4 months RH

Vit D3, 0.25 mg,oral

Ralph 2013 [20]

Indonesia

NCT00677339

2 months HRZE then 4 months RH

Vit D3,1.25 mg, and L-arginine,6 g,oral

Salahuddin 2013 [14]

Pakistan

NCT01130311

2 months HRZE, then6 months HE

Vit D3,15 mg, intramuscular

Tukvadze 2015 [39]

Georgia

NCT00918086

2 months HRZE then 4 months RH

Vit D3,1.25 mg, oral

Wejse 2009 [38]

Guinea-Bissau

ISRCTN35212132

2 months HRZE, then 6 months HE

Vita D3, 2.5 mg,oral

Johnson 2003 [40]

Uganda

NM

2 months HRZE then 4 months RH

rIL-2,11.2 mg,intradermal

Mayanja-Kizza 2005 [41]

Uganda

NM

2 months HRZE then 4 months RH

Prednisolone, 2.75 mg,oral

Pedral-Sampaio 2003 [44]

Brazil

NM

2 months HRZ then 4 months RH

Rhu-GM-CSF,125 μg, subcutaneous

Willis 1996 [42]

Ugandan

NM

2 months HRZ then 4 months RH

Pentoxifylline,1800 mg,oral

Mahakalkar 2017 [43]

India

not registered

2 months HRZ then 4 months RH

N-acetylcysteine,600 mg,oral

Ganmaa 2017 [15]

Mongolia

NCT01657656

2 months HRZE

vit D3, 3.5 mg,oral

  1. NM not mentioned, Vit Vitamins, HRZE isoniazid,rifampicin, pyrazinamide, ethambutol, RH rifampicin & isoniazid, HE isoniazid & ethambutol, mg milligram, μg microgram, g gram, PBA phenylbutyrate, Rhu-GM-CSF recombinant human granulocyte-macrophage colony-stimulating factor, rIL recombinant human Interleukin, UK United kingdom, Anti-TB Anti-tuberculosis, vit D3 vitamin D3