Usefulness of surgical lung biopsies after cryobiopsies when pathological results are inconclusive or show a pattern suggestive of a nonspecific interstitial pneumonia

Table 3 Results of the pathological review of paired TBLCs and SLBs samples by the three experienced pathologists in ILD

		Pathologist			Mean (SD)
		MR	DH	FD	Mean (SD)
Change in histological diagnosis following SLB (excluding limited changes in confidence level) % (N/Number of patients with TBLC and SLB)		64 (9/14)	57 (8/14)	57 (8/14)	60 (4)
Additional informations provided by SLB (including changes in confidence level) % (N/Number of patients with TBLC and SLB)		93 (13/14)	71 (10/14)	79 (11/14)	81 (11)
Major determinants	Localisation of the biopsy in different lobes	23 (3/13)	10 (1/10)	36 (4/11)	23 (13)
	Size of the biopsies	69 (9/13)	100 (10/10)	100 (11/11)	90 (18)
	Localisation (subpleural vs bronchiolocentric)	46 (6/13)	30 (3/10)	73 (8/11)	50 (22)

Each pathologist (MR, DH, and FD) provides the most probable histological diagnosis for the 14 patients having both SLBs and TBLCs. For each patient and pathologist, change in histological diagnosis was recorded (row 1) as well as change in histological and/or confidence level (row 2). When SLB provide additional information (including only changes in confidence level), it was asked to the pathologist to describe the main reasons (row 3)

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