Table 1 Baseline patient characteristics
Characteristic | ≤ 150 cells/μL (n = 10,096) | > 150–≤ 300 cells/μL (n = 7581) | > 300 cells/μL (n = 4448) | Total (N = 22,125) |
|---|---|---|---|---|
Male, n (%) | 7120 (70.5) | 5694 (75.1) | 3584 (80.6) | 16,398 (74.1) |
Mean age, years (SD) | 65.3 (8.6) | 65.0 (8.6) | 64.6 (8.7) | 65.1 (8.6) |
Smoking status, n (%) | ||||
 Never smoked | 0 (0.0) | 0 (0.0) | 1 (0.0) | 1 (0.0) |
 Ex-smoker | 6299 (62.4) | 4788 (63.2) | 2897 (65.1) | 13,984 (63.2) |
 Current smoker | 3797 (37.6) | 2793 (36.8) | 1550 (34.8) | 8140 (36.8) |
 Smoking history, mean pack-years (SD) | 45.6 (26.0) | 45.7 (25.3) | 45.0 (25.7) | 45.5 (25.7) |
Moderate-to-severe exacerbations in previous year, n (%) | ||||
 0 | 2850 (28.2) | 2416 (31.9) | 1347 (30.3) | 6613 (29.9) |
 1 | 4672 (46.3) | 3229 (42.6) | 1907 (42.9) | 9808 (44.3) |
 2 | 1565 (15.5) | 1195 (15.8) | 709 (15.9) | 3469 (15.7) |
 3 | 533 (5.3) | 385 (5.1) | 251 (5.6) | 1169 (5.3) |
 4 | 220 (2.2) | 145 (1.9) | 107 (2.4) | 472 (2.1) |
  > 4 | 256 (2.5) | 211 (2.8) | 127 (2.9) | 594 (2.7) |
Severe exacerbations in previous year, n (%) | ||||
 0 | 8265 (81.9) | 6362 (83.9) | 3683 (82.8) | 18,310 (82.8) |
 1 | 1501 (14.9) | 970 (12.8) | 614 (13.8) | 3085 (13.9) |
 2 | 258 (2.6) | 198 (2.6) | 115 (2.6) | 571 (2.6) |
 3 | 44 (0.4) | 31 (0.4) | 19 (0.4) | 94 (0.4) |
 4 | 19 (0.2) | 12 (0.2) | 8 (0.2) | 39 (0.2) |
  > 4 | 9 (0.1) | 8 (0.1) | 9 (0.2) | 26 (0.1) |
 Mean pre-bronchodilator FEV1 at screening; L (SD) | 1.15 (0.45) | 1.18 (0.46) | 1.16 (0.46) | 1.16 (0.46) |
 ICS use at baseline, n (%) | 6149 (60.9) | 4477 (59.1) | 2669 (60.0) | 13,295 (60.1) |