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Fig. 5 | Respiratory Research

Fig. 5

From: FGL1 regulates acquired resistance to Gefitinib by inhibiting apoptosis in non-small cell lung cancer

Fig. 5

Effect of FGL1 knockdown on caspase 3 and PARP1 protein level in PC9/GR cells and removed tumors measured by western blot analysis (x ± s, n = 3). a Western blot analysis was applied to determine the effect of FGL1 on EGFR, p-EGFR, caspase 3, and PARP1 protein in NSCLC acquired-resistant cell line PC9/GR. b Western blot analysis was applied to determine the effect of FGL1 on EGFR, p-EGFR, caspase 3 and PARP1 protein expression in tumor tissues. Control: blank control group; NC-siRNA: mice transfected with NC-siRNA; Gefitinib: mice treated with gefitinib alone; FGL1-siRNA: mice treated with FGL1-siRNA-transfected cells; gefitinib+FGL1-siRNA: mice transfected with FGL1-siRNA cells and treated with gefitinib. *P < 0.05 compared with control group; **P < 0.01 compared with control group; #P < 0.05 compared with gefitinib group; △P < 0.01 compared with FGL1-siRNA group; &P < 0.01 compared PC9 cells

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Respiratory Research

ISSN: 1465-993X

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