Table 1 [A]: Descriptive characteristics of the patients included in the study; [B]: Linear regression model for the effect of various parameters in the upright RYAN score in the pre-defined cohort with 2-year follow-up
From: Laryngopharyngeal reflux in chronic obstructive pulmonary disease - a multi-centre study
[A] | ||||
Descriptive characteristics | All patients n = 193 | Pre-defined cohort with 2-year follow-up n = 107 | ||
Age (years), mean (SD) | 66.2 (8.8) | 67.5 (8.4) | ||
BMI (kg/m2), mean (SD) | 27.1 (6.7) | 27.8 (6.6) | ||
Medical history of GERD, n (%) | 33 (17) | 16 (15) | ||
Treated with PPI, n (%) | 69 (37) | 33 (30.8) | ||
Gender, male (%) | 119 (62) | 75 (70) | ||
Smoking status, n (%) | ||||
Current | 62 (34) | 38 (36) | ||
Past | 121 (66) | 69 (64) | ||
GOLD Stage, n (%) | ||||
I | 25 (14) | 6 (6) | ||
II | 82 (45) | 58 (58) | ||
III | 55 (30) | 32 (32) | ||
IV | 21 (11) | 4 (4) | ||
COPD Medication | ||||
LABA | 55 (28) | 19 (18) | ||
LABA+ICS | 151 (78) | 102 (96) | ||
LAMA | 129 (67) | 81 (76) | ||
SABA | 26 (13) | 2 (2) | ||
SAMA | 39 (20) | 35 (33) | ||
Lung Function (post-BD), mean (SD) | ||||
FEV1%predicted | 56.9 (21.8) | 57.4 (16.4) | ||
RV % predicted | 144.3 (49.4) | 136.6 (46.7) | ||
TLC %predicted | 110.5 (20.5) | 107.9 (20.5) | ||
DLCO% predicted | 61.0 (22.8) | 57.7 (18.5) | ||
FEV1/FVC | 46.9 (14.1) | 46.9 (13.1) | ||
Questionnaire scores, mean (SD) | ||||
GerdQ | 2.1 (3.3) | 2.1 (3.2) | ||
Leicester cough | 96.5 (38.0) | 104.6 (27.1) | ||
RSI | 10.0 (9.2) | 10.1 (8.4) | ||
[B] | ||||
Parameter | Pre-defined cohort with 2-year follow-up (n = 107) | |||
Beta | 95% CI: Lower | 95% CI: Upper | p-value | |
Age | 0.239 | 0.006 | 0.050 | 0.013 |
6MWT | −0.073 | −0.002 | 0.001 | 0.474 |
BODE Index | 0.004 | −0.099 | 0.103 | 0.969 |
Lung Function | ||||
FEV1% predicted | −0.010 | −0.013 | 0.012 | 0.923 |
TLC % predicted | −0.182 | −0.019 | 0.001 | 0.091 |
RV % predicted | −0.142 | −0.007 | 0.001 | 0.177 |
Νumber of exacerbations during the study | 0.015 | −0.175 | 0.205 | 0.877 |
Number of severe exacerbations during the study | −0.011 | −0.305 | 0.272 | 0.911 |
Questionnaires | ||||
GerdQ | −0.257 | −0.139 | − 0.022 | 0.008 |
Leicester cough | 0.012 | −0.007 | 0.008 | 0.899 |
RSI | −1.013 | −0.034 | 0.011 | 0.314 |