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Table 4 Multivariable logistic regression models of the association between gastroesophageal reflux disease (GERD) and rapid FEV1 decline (FEV1 decline of ≥40 mL/year, n = 2572). Adjusted odds ratios reflect the relative odds of rapid FEV1 decline between those with GERD, compared to those without GERD

From: Impact of gastroesophageal reflux on longitudinal lung function and quantitative computed tomography in the COPDGene cohort

 

Adjusted Odds Ratio

(95% CI)

Any GERD (n = 2101)

1.20 (1.07, 1.35)

Persistent GERD (n = 1080)

1.23 (1.06, 1.43)

Incident GERD (n = 604)

1.33 (1.11, 1.60)

Resolved GERD (n = 417)

1.01 (0.82, 1.26)

  1. Adjustment was made for the following variables: age, sex, race, smoked between phase I and II, BMI, clinical center, FEV1% predicted at Phase I, and acute exacerbation ≥1 between phase I and II
  2. Definitions: Any GERD, Phase I = ‘yes’ or Phase II = ‘yes’; Persistent GERD, Phase I = ‘yes’ and Phase II = ‘yes’; Incident GERD, Phase I = ‘no’ and Phase II = ‘yes’; and Resolved GERD, Phase I = ‘yes’ and Phase II = ‘no’
  3. Abbreviations: GERD gastroesophageal reflux disease, FEV1 forced expiratory volume in 1 s and CI confidence interval