| Model 1: Crude | Model 2: Age, sex, race, smoked between Phase I and II, BMI, clinical center, and FEV1% predicted at Phase I | Model 3: Model 2 + Acute exacerbations ≥ 1 between Phase I and Phase II |
---|---|---|---|
Unadjusted ß Estimate (95% CI) | Adjusted ß Estimate (95% CI) | Adjusted ß Estimate (95% CI) | |
Spirometry | |||
 FEV1 (mL/year) | −0.01 (−2.92, 2.89) | −3.64 (−6.56, − 0.73) | −2.53 (−5.43, 0.37) |
 FVC (mL/year) | −2.76 (− 6.93, 1.42) | −4.26 (−8.52, − 0.004) | −3.05 (− 7.29, 1.19) |
Quantitative CT chest | |||
 AWT-Pi10 (μm/year) | 2.31 (−1.86, 6.48) | 1.28 (− 2.91, 5.48) | 0.64 (−3.57, 4.84) |
 Airway wall area (%/year) | 0.037 (− 0.022, 0.097) | 0.013 (− 0.047, 0.073) | 0.003 (− 0.058, 0.063) |
 Air trapping (%/year) | 0.117 (0.006, 0.227) | 0.167 (0.063, 0.271) | 0.159 (0.054, 0.264) |
 Emphysema (%/year) | 0.035 (− 0.010, 0.081) | 0.015 (− 0.025, 0.055) | 0.012 (− 0.028, 0.052) |
 Perc15 lung density (HU/year) | − 0.073 (− 0.207, 0.061) | − 0.024 (− 0.137, 0.089) | −0.023 (− 0.137, 0.090) |