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Fig. 6 | Respiratory Research

Fig. 6

From: Functional glutamate transporters are expressed in the carotid chemoreceptor

Fig. 6

Schematic representation of glutamatergic neurotransmission in the CB. a. Under normoxia, glutamate released from CB pre-synaptic type I cell acts on glutamate ionotropic receptors on its corresponding post-synaptic type I cell. The influx of Na+ and Ca2+ ions cause depolarization and generation of action potential. b. CIH causes CB neuronal damages, then accumulation of glutamate induced neurotoxicity, leading compensatory reduction of VGluT2 and EAAT2 as well as an increase of EAAT3

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