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Table 4 Factors associated with BEC ≥ 400. Results of the logistic regression – Multivariable analysis - Backward stepwise predictive model (p < 0.2)

From: Chronic oral corticosteroids use and persistent eosinophilia in severe asthmatics from the Belgian severe asthma registry

BEC ≥ 400

Total population (n = 174)

UNIVARIATE

MULTIVARIATE

OR

95%CI

P-value

OR

95%CI

P-value

Age onset (< 12)

  ≥ 12; < 40

2.93

1.05–8.13

0.0009

13.6

1.6–116.8

0.0047

  ≥ 40

6.12

2.26–16.60

31.6

3.6–276.9

ACQ (< 1.6)

  ≥ 1.6; < 2.9

0.36

0.12–1.11

0.0926

0.29

0.08–1.00

0.0458

  ≥ 2.9; < 3.9

0.46

0.15–1.39

0.58

0.16–2.08

  ≥ 3.9

0.23

0.07–0.76

0.17

0.05–0.63

Atopy

0.66

0.35–1.20

0.176

  

NS

Smoking (Never)

 Current

0.53

0.12–2.35

0.0608

  

NS

 Ex

0.46

0.24–0.88

  

Age (< 48)

  ≥ 48; < 56

1.58

0.66–3.75

0.1448

  

NS

  ≥ 56; < 64

0.80

0.34–1.87

  

  ≥ 64

1.97

0.85–4.59

  

FEV1%

1.02

1.00–1.03

0.029

  

NS

Exhaled NO (ppb) (< 25)

  ≥ 25; < 50

1.83

0.76–4.45

0.0073

  

NS

  ≥ 50

4.13

1.70–10.00

  

Sputum Eosinophils % (< 0.4)

  ≥ 0.4; < 3.0

1.29

0.07–24.39

0.0437

  

NS

  ≥ 3.0; < 21.0

0.82

0.04–15.00

  

  ≥ 21.0

15

1.21–185.20

  

Sputum Neutrophils %

0.94

0.90–0.98

0.003

  

NS

Nasal polyposis

1.84

0.96–3.53

0.066

  

NS

  1. OR odds ratio, CI confidence interval, ACQ Asthma Control Questionnaire, FEV1 forced expiratory volume in 1 s, NO nitric oxide, ppb parts per billion. NS not significant
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Respiratory Research

ISSN: 1465-993X

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