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Table 4 Univariable and multivariable linear regression analyses of factors associated with overall satisfaction with medication (n = 78)

From: Patient expectations, experiences and satisfaction with nintedanib and pirfenidone in idiopathic pulmonary fibrosis: a quantitative study

 

Univariable analysis

Multivariable analysis

B (95% CI)

p-value

B (95% CI)

p-value

Age

0.019 (− 0.04;0.08)

0.55

Gender

−0.97 (−2.6;0.6)

0.25

Expectations effectiveness

0.54 (−0.15;1.2)

0.12

Expectations side-effects

−0.10 (− 0.85;0.65)

0.79

FVC % predicted

0.004 (−0.02;0.03)

0.76

DLCO % predicted

0.008 (−0.02;0.04)

0.60

  

Change in FVC % predicted*

0.05 (−0.005;0.01)

0.079

0.026 (−0.05;0.10)

0.64

Change in DLCO % predicted*

−0.04 (− 0.08;0.01)

0.11

Antifibrotic drug

0.24 (−0.62;1.1)

0.58

VAS - cough

−0.23 (− 0.39;-0.07)

0.005

  

VAS – dyspnea

−0.41 (− 0.56;-0.26)

< 0.001

  

VAS - general complaints

0.36 (0.15;0.57)

0.001

0.04 (−0.34;0.42)

0.84

HADS – anxiety score

−0.30 (− 0.47;-0.14)

0.001

− 0.23 (− 0.63;0.17)

0.24

HADS – depression score

− 0.24 (− 0.35;-0.13)

< 0.001

−0.01 (− 0.29;0.28)

0.95

Experiences effectiveness

1.2 (0.6;1.75)

< 0.001

0.95 (0.22;1.67)

0.01

Experiences side-effects

−0.53 (− 0.87;-0.18)

0.003

0.07 (− 0.67;0.82)

0.84

Experiences ease of use

−0.99 (−1.8;-0.17)

0.019

−0.34 (−1.99;1.31)

0.68

Severity score side-effects

−0.07 (− 0.11;− 0.03)

0.001

-0.03 (− 0.11;0.052)

0.49

  1. FVC forced vital capacity, DLCO diffusion capacity of the lung for carbon monoxide, HADS hospital anxiety and depression scale, VAS visual analogue scale, *change in FVC and DLCO between baseline and six months