Month 3 | Month 6 | |||||||
---|---|---|---|---|---|---|---|---|
Nintedanib (n = 37) | Pirfenidone (n = 46) | Difference (95% CI) | p-value | Nintedanib (n = 37) | Pirfenidone (n = 41) | Difference (95% CI) | p-value | |
Satisfaction with effectiveness | 1.7 (1.6) | 1.5 (1.6) | 0.2 (− 0.5–0.9) | 0.58 | 1.4 (1.7) | 1.7 (1.9) | 0.3 (− 1.1–0.6) | 0.54 |
Satisfaction with side-effects | 1.7 (2.0) | 1.8 (2.2) | 0.1 (− 1–0.9) | 0.9 | 1.3 (1.9) | 1.8 (2.2) | 0.4 (− 1.4–0.5) | 0.37 |
Satisfaction with ease of use | 3.2 (1.6) | 2.6 (1.6) | 0.6 (− 0.1–1.3) | 0.08 | 2.9 (1.4) | 2.5 (1.9) | 0.4 (−0.4–1.1) | 0.3 |
Overall satisfaction with medication | 2.2 (1.7) | 1.9 (1.8) | 0.2 (−0.5–1) | 0.53 | 1.9 (1.7) | 2.2 (2.0) | 0.2 (−1.1–0.6) | 0.58 |
Experiences with effectiveness | 1.7 (1.0) | 1.7 (0.9) | 0.09 (−0.7–0.5) | 0.75 | 2 (1.1) | 1.8 (1.0) | 0.2 (− 0.6–1) | 0.55 |
Experiences with side-effects | 3.1 (1.2) | 2.9 (1.2) | 0.3 (−0.3–0.8) | 0.41 | 2.8 (1.2) | 3.1 (1.1) | 0.3 (−0.8–0.2) | 0.25 |
Experiences with ease of use | 3.9 (0.3) | 3.8 (0.5) | 0.1 (−0.05–0.3) | 0.14 | 3.9 (0.3) | 03.7 (0.6) | 0.1 (−0.07–0.4) | 0.18 |
Number of reported side-effects per patient | 6.0 (3.5) | 6.6 (4.6) | 0.6 (−2.4–1.3) | 0.55 | 5.7 (4.2) | 5.7 (5.1) | 0.05 (−2–2.1) | 0.96 |
Severity score side-effects | 9.9 (13.2) | 9.8 (9.3) | 0.1 (−4.8–5.1) | 0.96 | 8.9 (9.5) | 8.3 (9.0) | 0.6 (−3.3–4.5) | 0.75 |