Cold-inducible RNA-binding protein might determine the severity and the presences of major/minor criteria for severe community-acquired pneumonia and best predicted mortality

Table 7 AUC values for different rules to predict mortality and their comparisons

Feature	AUC value	Standard error	95% CI
CIRP	0.873	0.0269	0.836–0.904
PCT	0.795	0.0349	0.753–0.834
IL-6	0.766	0.0360	0.721–0.806
CRP	0.768	0.0365	0.724–0.808
SOFA	0.845	0.0306	0.806–0.879
PSI	0.859	0.0310	0.821–0.891
Minor criteria	0.663	0.0421	0.615–0.709
	Difference	z statistic	p value
CIRP ~ PCT	0.0774	3.503	0.0005
CIRP ~ IL-6	0.107	4.883	< 0.0001
CIRP ~ CRP	0.105	4.683	< 0.0001
CIRP ~ PSI	0.0142	0.883	0.3774
CIRP ~ Minor criteria	0.210	5.892	< 0.0001
PCT ~ IL-6	0.0295	1.527	0.1268
PCT ~ CRP	0.0273	1.308	0.1908
PCT ~ PSI	0.0632	3.167	0.0015
PCT ~ Minor criteria	0.132	4.338	< 0.0001
IL-6 ~ CRP	0.00215	0.0961	0.9234
IL-6 ~ PSI	0.0926	4.994	< 0.0001
IL-6 ~ Minor criteria	0.103	3.427	0.0006
CRP ~ PSI	0.0905	4.818	< 0.0001
CRP ~ Minor criteria	0.105	3.883	0.0001
PSI ~ Minor criteria	0.196	6.483	< 0.0001

AUC The area under the receiver operating characteristic curve, CI Confidence interval, CIRP Cold-inducible RNA-binding protein, PCT Procalcitonin, IL-6 Interleukin-6, CRP C-reactive protein, PSI Pneumonia severity index, SOFA Sequential organ failure assessment

ISSN: 1465-993X