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Table 3 CIRP, PCT, IL-6, CRP, SOFA and PSI scores, and mortality according to the IDSA/ATS major/minor criteria present (Mean ± SD, n = 404)

From: Cold-inducible RNA-binding protein might determine the severity and the presences of major/minor criteria for severe community-acquired pneumonia and best predicted mortality

CAP patients

CIRP (ng/mL)

PCT

(ng/mL)

IL-6

(pg/mL)

CRP

(mg/L)

SOFA score

PSI score

Death (%)

Severe CAP patients meeting the major criteria (n = 16)

5.82 ± 0.75

2.90 ± 0.49

181.45 ± 15.01

135.52 ± 13.78

6.88 ± 1.41

153.69 ± 10.74

8 (50)

Severe CAP patients meeting three of the most predictive minor criteria (n = 28)

4.51 ± 0.49

2.33 ± 0.55

163.00 ± 16.36

117.25 ± 15.77

5.86 ± 1.38

134.57 ± 5.65

8 (28.6)

Severe CAP patients meeting two of the most predictive minor criteria (n = 60)

3.41 ± 0.27

1.82 ± 0.47

140.37 ± 11.47

82.93 ± 11.80

3.90 ± 1.49

125.50 ± 6.05

10 (16.7)

Severe CAP patients meeting one of the most predictive minor criteria (n = 60)

2.78 ± 0.31

0.96 ± 0.29

130.12 ± 10.20

71.69 ± 11.33

3.23 ± 1.51

117.22 ± 6.87

7 (11.7)

Severe CAP patients meeting none of the most predictive minor criteria (n = 60)

1.67 ± 0.11

0.31 ± 0.09

67.08 ± 5.97

23.65 ± 5.75

1.53 ± 1.50

65.60 ± 4.79

2 (3.3)

Non-severe CAP patients meeting two of the most predictive minor criteria (n = 60)

2.85 ± 0.31

0.74 ± 0.36

121.61 ± 8.25

51.44 ± 12.50

3.48 ± 1.55

108.40 ± 5.34

5 (8.3)

Non-severe CAP patients meeting one of the most predictive minor criteria (n = 60)

2.27 ± 0.50

0.53 ± 0.11

108.84 ± 7.04

37.60 ± 10.92

3.03 ± 1.55

74.02 ± 6.57

4 (6.7)

Non-severe CAP patients meeting none of the most predictive minor criteria (n = 60)

0.92 ± 0.13

0.20 ± 0.08

36.45 ± 16.08

11.45 ± 5.48

0.52 ± 0.79

36.75 ± 2.38

0 (0)

F or x2 value

643.360

333.307

790.423

586.484

75.037

2003.649

48.707

p value

<  0.001

<  0.001

<  0.001

<  0.001

<  0.001

<  0.001

<  0.001

Rank correlation coefficient (rs) value

0.786

0.806

0.811

0.836

0.579

0.858

0.275

p value

<  0.001

<  0.001

<  0.001

<  0.001

<  0.001

<  0.001

<  0.001

  1. CIRP Cold-inducible RNA-binding protein, PCT Procalcitonin, IL-6 Interleukin-6, CRP C-reactive protein, SOFA Sequential organ failure assessmentm, PSI Pneumonia severity index, IDSA/ATS The Infectious Disease Society of America and the American Thoracic Society, CAP community-acquired pneumonia