Skip to main content
Fig. 6 | Respiratory Research

Fig. 6

From: LPS aggravates lung inflammation induced by RSV by promoting the ERK-MMP-12 signaling pathway in mice

Fig. 6

MMP-12 contributed to lung inflammation and AHR provoked by LPS during the later stage of RSV infection. MMP-12 levels (a), inflammatory cells in BALF (b), pathological damage of lung tissues (c-h) and AHR (i) were noteworthy alleviated by MMP-408. Representative HE staining: original Magnification × 200, c: control group; d: RSV group; e: LPS group; f: RSV + LPS group; g: RSV + LPS+ i MMP-12 group; h: Histological scores. Graphs are represented as the mean ± sem. Data are representative of two independent experiments performed on 6 animals per group. *, p < 0.05, **, p < 0.01, ***, p < 0.001, shown comparing the control group with the RSV + LPS group; #, p < 0.05, ##, p < 0.01, ###, p < 0.001, shown comparing the RSV + LPS group with the LPS group; ^, p < 0.05, ^^, p < 0.01, ^^^, p < 0.001, shown comparing the RSV + LPS group with the RSV group; ϕ, p < 0.05, ϕ ϕ, p < 0.01, ϕ ϕ ϕ, p < 0.001, shown comparing the RSV + LPS group with the RL + i MMP-12 group

Back to article page