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Fig. 1 | Respiratory Research

Fig. 1

From: Possible reversibility between epithelioid and sarcomatoid types of mesothelioma is independent of ERC/mesothelin expression

Fig. 1

Effects of ERC/mesothelin expression on mesothelioma cells. a, Effects of ERC/mesothelin overexpression (left column) or knockdown (right column) on the morphology of H2452 or H226 cells, respectively, as observed by phase-contrast microscopy (objective lens × 10). Top panels: parental H2452 or H226; Middle panels: H2452 overexpressing ERC/mesothelin or H226 treated with siRNA of ERC/mesothelin; Bottom panels: H2452 or H226 treated with control vector or control siRNA. b, Effects of ERC/mesothelin overexpression on the expression of E-cadherin, vimentin and MMP-9 assessed by western blotting. Note that MESO4 (ACC-MESO-4) and H226 cells were used as positive and negative controls, respectively, for E-cadherin. c, Effects of three siRNAs of ERC/mesothelin (si5, si6, si7) on expression. RFP, red fluorescent protein; MMP-9, matrix metalloproteinase-9

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Respiratory Research

ISSN: 1465-993X

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