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Table 1 Healthy and COPD subject characteristics

From: The sputum microbiome is distinct between COPD and health, independent of smoking history

  Healthy control (n = 124) Healthy control
PY ≥10 (n = 28)
Healthy control
PY < 10 (n = 96)
COPD (n = 218) p-value*
Gender female (n) 73 15 58 60 < 0·0001
Age (years) 61 (54, 67) 65 (58, 69) 59 (53, 67) 69 (64,74) < 0·0001
BMI 27·7 (24·3, 31·2) 29·3 (25·8, 34·4) 27·3 (24·2, 29·9) 26·7 (23·32,30·06) 0·0325
Smoking history (Pack years) 0 (0, 8) 29 (17·3, 45·8) 0 (0,0) 46 (34,64) < 0·0001
MRC Dyspnoea scale 0 (0, 1) 0 (0, 1) 0 (0, 1) 2 (1,2) < 0·0001
VAS dyspnoea (mm scale) 0 (0, 2) 0 (0, 3.5) 0 (0, 2) 30 (15,49) < 0·0001
Post BD FEV1 (L) 2·87 (2·43, 3·37) 2·82 (2·33, 3·24) 2·88 (2·46, 3·40) 1·45 (1·03,1·86) < 0·0001
Post BD FEV1% Predicted 109 (100, 118) 105 (92, 118) 110 (100, 118) 57 (42, 69) < 0·0001
Post BD FEV1/FVC % 80 (77, 83) 78 (75,82) 80 (78, 83) 51 (41,59) < 0·0001
Blood White cell count (×10^9/L) 5·8 (4·9, 7·3) 6·4 (5·1, 7·5) 5·7 (4·8, 7·25) 7·2 (6·3,8·8) < 0·0001
Blood Neutrophil count (× 10^9/L) 3·3 (2·7, 4·2) 3·8 (2·8, 4·3) 3·2 (2·6, 4·1) 4·7 (3·9, 5·7) < 0·0001
Blood Eosinophil count (× 10^9/L) 0·14 (0·09, 0·23) 0·18 (0·11, 0·25) 0·14 (0·09, 0·22) 0·21 (0·14, 0·27) < 0·0001
Sputum TCC (×106/g) 2·4 (1·1, 4·2) 3·19 (1·6, 5·9) 2·2 (1, 3·6) 10·5 (4·7,13·0) < 0·0001
Sputum eosinophils % 0·25 (0, 0·75) 0·25 (0·18, 2·38) 0·25 (0, 0·75) 0·75 (0,2) 0·0029
Sputum neutrophil (%) 60 (43, 74) 65 (42, 75) 56 (43, 73) 75 (40, 89) 0·0011
  1. Data is expressed as median (IQR). BMI body mass index, Sputum TCC sputum total cell count, FEV1 forced expiratory volume in 1 s, Post BD FEV1 spirometry recording post bronchodilator; FVC forced vital capacity. * = represents Kruskal-Wallis test comparing between healthy (PY ≥10), healthy (PY < 10) and COPD