Table 1 Healthy and COPD subject characteristics
From: The sputum microbiome is distinct between COPD and health, independent of smoking history
|  | Healthy control (n = 124) | Healthy control PY ≥10 (n = 28) | Healthy control PY < 10 (n = 96) | COPD (n = 218) | p-value* |
|---|---|---|---|---|---|
Gender female (n) | 73 | 15 | 58 | 60 | < 0·0001 |
Age (years) | 61 (54, 67) | 65 (58, 69) | 59 (53, 67) | 69 (64,74) | < 0·0001 |
BMI | 27·7 (24·3, 31·2) | 29·3 (25·8, 34·4) | 27·3 (24·2, 29·9) | 26·7 (23·32,30·06) | 0·0325 |
Smoking history (Pack years) | 0 (0, 8) | 29 (17·3, 45·8) | 0 (0,0) | 46 (34,64) | < 0·0001 |
MRC Dyspnoea scale | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 2 (1,2) | < 0·0001 |
VAS dyspnoea (mm scale) | 0 (0, 2) | 0 (0, 3.5) | 0 (0, 2) | 30 (15,49) | < 0·0001 |
Post BD FEV1 (L) | 2·87 (2·43, 3·37) | 2·82 (2·33, 3·24) | 2·88 (2·46, 3·40) | 1·45 (1·03,1·86) | < 0·0001 |
Post BD FEV1% Predicted | 109 (100, 118) | 105 (92, 118) | 110 (100, 118) | 57 (42, 69) | < 0·0001 |
Post BD FEV1/FVC % | 80 (77, 83) | 78 (75,82) | 80 (78, 83) | 51 (41,59) | < 0·0001 |
Blood White cell count (×10^9/L) | 5·8 (4·9, 7·3) | 6·4 (5·1, 7·5) | 5·7 (4·8, 7·25) | 7·2 (6·3,8·8) | < 0·0001 |
Blood Neutrophil count (× 10^9/L) | 3·3 (2·7, 4·2) | 3·8 (2·8, 4·3) | 3·2 (2·6, 4·1) | 4·7 (3·9, 5·7) | < 0·0001 |
Blood Eosinophil count (× 10^9/L) | 0·14 (0·09, 0·23) | 0·18 (0·11, 0·25) | 0·14 (0·09, 0·22) | 0·21 (0·14, 0·27) | < 0·0001 |
Sputum TCC (×106/g) | 2·4 (1·1, 4·2) | 3·19 (1·6, 5·9) | 2·2 (1, 3·6) | 10·5 (4·7,13·0) | < 0·0001 |
Sputum eosinophils % | 0·25 (0, 0·75) | 0·25 (0·18, 2·38) | 0·25 (0, 0·75) | 0·75 (0,2) | 0·0029 |
Sputum neutrophil (%) | 60 (43, 74) | 65 (42, 75) | 56 (43, 73) | 75 (40, 89) | 0·0011 |