Characteristics | Non-smokersa (N = 28) | Smokersa (N = 27) | COPD GOLD stage I-II (N = 27) | COPD GOLD stage III-IV (N = 33) | P valuec |
---|---|---|---|---|---|
Number of males (%) | 18 (64.3) | 17 (63) | 23 (85) | 20 (60.6) | NS |
Age (years) | 66 (35–77) | 62 (50–74) | 67 (53–83) | 65 (48–82) | NS |
Pack-yrs. of smoking | 0 | 50 (15–96) | 60 (20–127) | 68 (12–160) | P ≤ 0.049d |
Number of current smokers (%) | 0 (0) | 3 (10) | 14 (52) | 7 (21) | P ≤ 0.03e |
FEV1(% of predicted)b | 98 (79–147) | 91 (65–119) | 65 (50–105) | 35 (17–49) | P < 0.001f |
FEV1/FVC (% of predicted)b | 77 (70–86) | 76 (71–84) | 57 (38–68) | 39 (26–59) | P < 0.001g |
Plasma sADAM15 Levels (pg/ml) | 665 (175–2457) | 642 (256–2393) | 517 (64–1110) | 672 (54–3533) | NSh |