Fig. 5

Single cell RNA-sequencing analysis of ACE2, TMPRSS2. ADAM17, TIMP3, TGFB1, CTGF, VEGFA and FN1 mRNA in human lungs from patients with idiopathic pulmonary fibrosis (IPF). a Single cells were isolated from cryobiopsy samples in one IPF patient. They were subjected to RNA-sequencing and data clustered using a graph-based shared nearest neighbour clustering approach and visualised using a t-distributed Stochastic Neighbor Embedding (tSNE) plot from UCSC cell browser. b mRNA expression of ACE2, TMPRSS2, ADAM17, TIMP3, TGFB1, CTGF, VEGFA and FN1 in different cells from human airways. c Single cells were isolated from human lungs from IPF patients (n = 8), subjected to RNA-sequencing and data clustered using tSNE plot from UCSC cell browser. d mRNA expression of ACE2, TMPRSS2, ADAM17, TIMP3, AGT, TGFB1, CTGF, VEGFA and FN1 in different cells from human lungs