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Table 3 Lung function and prevalence of ACO in cohorts of SAAS and COREA

From: Relationship between age and bronchodilator response at diagnosis in adult-onset asthma

 

Age at asthma diagnosis

<  40 years

Age at asthma diagnosis

40–59.9 years

Age at asthma diagnosis

≥ 60 years

p-value

SAAS cohort

 FEV1 L post BD

3.34 (2.90–4.17)

2.87 (2.40–3.36) a

2.01 (1.75–2.50) a,b

< 0.001

 FEV1% pred post BD

90 (84–100)

86 (74–99)

79 (60–89) a,b

< 0.001

 FEV1/FVC post BD

0.81 (0.75–0.87)

0.78 (0.73–0.83) a

0.73 (0.62–0.79) a,b

< 0.001

 FVC % pred post BD

95 (88–103)

92 (78–103)

87 (73–98) a

0.012

 DLco % predictedc

100 ± 20

95 ± 19

92 ± 18

0.093

 DL/VA % predictedc

104 ± 19

98 ± 19

97 ± 15

0.106

 ACOd

3 (3.7%)

11 (9.7%)

10 (22.2%) a

0.004

COREA cohort

 FEV1 L post BD

2.74 ± 0.90

2.23 ± 0.69 a

1.70 ± 0.57 a,b

< 0.001

 FEV1% pred post BD

84 ± 21

82 ± 23

75 ± 24 a,b

< 0.001

 FEV1/FVC post BD

0.77 ± 0.13

0.72 ± 0.13 a

0.66 ± 0.15 a,b

< 0.001

 FVC% pred post BD

90 ± 16

90 ± 17

84 ± 21 a,b

< 0.001

 ACOd

17 (6.9%)

55 (17.4%)

82 (36.6%)

< 0.001

  1. Data is shown as n (%), mean ± SD or median (interquartile range). DLco Diffusing capacity of the lung for carbon monoxide, VA Alveolar volume
  2. a: as compared to group: Age at asthma diagnosis < 40 years p < 0.05
  3. b as compared to group: Age at asthma diagnosis 40–59.9 years p < 0.05
  4. c Data available from 64 (77.1%), 86 (74.8%) and 33 (70.2%) of patients, respectively
  5. dACO: post BD FEV1/FVC < 0.7 and pack-years ≥10