From: Relationship between age and bronchodilator response at diagnosis in adult-onset asthma
Age at asthma diagnosis < 40 years | Age at asthma diagnosis 40–59.9 years | Age at asthma diagnosis ≥ 60 years | p-value | |
---|---|---|---|---|
SAAS cohort | ||||
FEV1 L post BD | 3.34 (2.90–4.17) | 2.87 (2.40–3.36) a | 2.01 (1.75–2.50) a,b | < 0.001 |
FEV1% pred post BD | 90 (84–100) | 86 (74–99) | 79 (60–89) a,b | < 0.001 |
FEV1/FVC post BD | 0.81 (0.75–0.87) | 0.78 (0.73–0.83) a | 0.73 (0.62–0.79) a,b | < 0.001 |
FVC % pred post BD | 95 (88–103) | 92 (78–103) | 87 (73–98) a | 0.012 |
DLco % predictedc | 100 ± 20 | 95 ± 19 | 92 ± 18 | 0.093 |
DL/VA % predictedc | 104 ± 19 | 98 ± 19 | 97 ± 15 | 0.106 |
ACOd | 3 (3.7%) | 11 (9.7%) | 10 (22.2%) a | 0.004 |
COREA cohort | ||||
FEV1 L post BD | 2.74 ± 0.90 | 2.23 ± 0.69 a | 1.70 ± 0.57 a,b | < 0.001 |
FEV1% pred post BD | 84 ± 21 | 82 ± 23 | 75 ± 24 a,b | < 0.001 |
FEV1/FVC post BD | 0.77 ± 0.13 | 0.72 ± 0.13 a | 0.66 ± 0.15 a,b | < 0.001 |
FVC% pred post BD | 90 ± 16 | 90 ± 17 | 84 ± 21 a,b | < 0.001 |
ACOd | 17 (6.9%) | 55 (17.4%) | 82 (36.6%) | < 0.001 |