Fig. 5
From: The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of experimental allergic asthma
IL-17RE deficiency effects methacholine-induced AHR. OVA-sensitized and challenged WT and Il-17re−/− mice were intranasally treated with 100 μg pIC or PBS as control 2 h after the final OVA challenge and analyzed after 22 h. Non-sensitized (PBS) control mice were treated with PBS. Mice were provoked with increasing concentrations of methacholine and the airway responsiveness was measured. Data were compared by Two-way ANOVA with Tukey’s post-test and are shown as the mean ± SEM. **p < 0.01 indicate a significant difference compared to corresponding OVA-sensitized and challenged control mice. n = 6–7 per group