From: Role of serum periostin in severe obstructive sleep apnea with albuminuria: an observational study
Index | Mild/moderate OSAan = 43 | Severe OSAa alone n = 41 n = 41 | Severe OSAa + high periostinb n = 12 | p-value‡ |
---|---|---|---|---|
Age, years | 60 ± 10 | 58 ± 12 | 63 ± 9 | 0.16 |
Sex, male/female, n | 33/10 | 31/10 | 10/2 | 0.57 |
Smoking, current/others, n | 12/31 | 8/33 | 1/11 | 0.36 |
BMI, kg/m2 | 26.2 ± 3.5 | 28.9 ± 4.6 | 28.6 ± 3 | 0.83 |
AHI, events/h | 18.8 ± 6.9 | 51.1 ± 17.5 | 50 ± 13.5 | 0.90 |
CT90, % | 5.5 ± 8.0 | 21 ± 22.7 | 13.8 ± 14.8 | 0.59 |
3% ODI, events/h | 17.5 ± 7.3 | 48.5 ± 18.6 | 46.1 ± 13.4 | 0.83 |
Lowest oxygen saturation, % | 82.6 ± 7.6 | 76 ± 7.5 | 75.6 ± 8.4 | 0.98 |
Arousal index, events/h | 21.8 ± 8.8 | 45.4 ± 17.8 | 41.8 ± 12.6 | 0.51 |
Serum periostin, ng/mL | 64.7 ± 22.4 | 59.7 ± 13.9 | 102.7 ± 15.4 | – |
Blood eosinophils, /μL | 202 (124–350) | 219 (131–299) | 240 (155–284) | 0.92 |
Total cholesterol, mg/dL | 195 ± 32 | 199 ± 37 | 189 ± 32 | 0.40 |
High-density lipoprotein, mg/dL | 55 ± 16 | 53 ± 13 | 48 ± 15 | 0.30 |
Low-density lipoprotein, mg/dL | 114 ± 34 | 121 ± 28 | 111 ± 21 | 0.22 |
Triglycerides, mg/dL | 158 ± 90 | 175 ± 148 | 207 ± 117 | 0.49 |
Free fatty acids, mg/dL | 480 ± 172 | 474 ± 147 | 581 ± 139 | 0.03 |
Blood glucose, mg/dL | 100 ± 23 | 100 ± 23 | 113 ± 33 | 0.12 |
Hemoglobin A1c, % | 6.2 ± 0.9 | 6.1 ± 0.8 | 6.5 ± 1.1 | 0.19 |
Dyslipidemia, +/−, n | 15/28 | 16/25 | 7/5 | 0.24 |
Diabetes mellitus, +/−, n | 14/29 | 7/34 | 5/7 | 0.07 |
Hypertension, +/−, n | 22/21 | 29/12 | 8/4 | 0.79 |
Urinary albumin–creatinine ratioc, mg/g | 10.5 ± 15.9 | 22.5 ± 89.4 | 89.4 ± 258.5 | 0.31 |
Albuminuriad, macro/micro/−, n | 0/6/37 | 1/3/37 | 1/3/8 | 0.04e |
Chronic obstructive pulmonary disease, +/−, n | 1/41 | 0/41 | 1/11 | 0.06 |
Asthma, +/−, n | 1/42 | 1/40 | 2/10 | 0.06 |
Allergic rhinitis, +/−, n | 8/35 | 6/35 | 2/10 | 0.89 |