From: Predictors of fatality including radiographic findings in adults with COVID-19
Normal range | Total (n = 102) | Non-survivor (n = 15) | Survivor (n = 87) | p value | |
---|---|---|---|---|---|
White blood cell count, × 109/L | 4.00–10.00 | 6.0 (4.4–8.6) | 9.1 (5.5–11.2) | 5.8 (4.4–8.1) | 0.011 |
< 4 | 11 (11%) | 1 (7%) | 10 (11%) | 0.019 | |
4–10 | 75 (74%) | 8 (53%) | 67 (78%) | .. | |
> 10 | 16 (15%) | 6 (40%) | 10 (11%) | .. | |
Neutrophil count, × 109/L | 1.80–6.30 | 4.2 (2.9–6.8) | 8.0 (3.5–10.6) | 4.1 (2.8–6.2) | 0.006 |
Lymphocyte count, × 109/L | 1.10–3.20 | 0.9 (0.6–1.2) | 0.5 (0.4–0.8) | 0.9 (0.7–1.2) | 0.006 |
< 1·1 | 66 (65%) | 12 (80%) | 54 (62%) | 0.180 | |
≥1·1 | 36 (35%) | 3 (20%) | 33 (38%) | .. | |
Hemoglobin, g/L | 130.0–175.0 | 128.0 (115.0–138.0) | 120.0 (110.0–135.0) | 128.0 (115.0–139.0) | 0.571 |
Platelet count, × 109/L | 125.0–350.0 | 194.0 (152.0–250.5) | 113.0 (97.0–165.0) | 206.5 (162.8–267.5) | 0.001 |
< 125 | 16/101 (16%) | 9 (60%) | 7/86 (8%) | 0.000 | |
≥125 | 85/101 (84%) | 6 (40%) | 79/86 (92%) | .. | |
Lactate dehydrogenase, U/L | 135–225 | 294.5 (219.3–417.5) | 569.0 (362.0–664.0) | 272.0 (205.0–383.0) | 0.000 |
≤225 | 27 (26%) | 1 (7%) | 26 (30%) | 0.060 | |
> 225 | 75 (74%) | 14 (93%) | 61 (70%) | .. | |
D-dimer, μg/mL | ≤0·5 | 0.8 (0.5–1.7) | 2.1 (1.2–4.4) | 0.7 (0.4–1.5) | 0.000 |
≤0·5 | 28 (27%) | 1 (7%) | 27 (31%) | 0.002 | |
> 0·5 to ≤1 | 29 (28%) | 1 (7%) | 28 (32%) | .. | |
> 1 | 45 (45%) | 13 (86%) | 32 (37%) | .. | |
Prothrombin time, s | 11.5–14.5 | 14.2 (13.7–14.8) | 14.9 (14.1–17.1) | 14.1 (13.6–14.5) | 0.001 |
< 14.5 | 65 (64%) | 4 (27%) | 61 (70%) | 0.001 | |
≥14.5 | 37 (36%) | 11 (73%) | 26 (30%) | .. | |
International Normalized Ratio, INR | 0.80–1.20 | 1.08 (1.04–1.15) | 1.16 (1.08–1.37) | 1.08 (1.02–1.12) | 0.001 |
Hypersensitive troponin I, pg/mL | ≤34.2 | 5.2 (2.2–16.2) | 24.1 (13.0–202.1) | 4.3 (2.0–10.6) | 0.000 |
≤34.2 | 88/101 (87%) | 8 (53%) | 80/86 (93%) | 0.000 | |
> 34.2 | 13/101 (13%) | 7 (47%) | 6/86 (7%) | .. | |
NT-proB-type Natriuretic Peptide (BNP), pg/mL | < 241 | 131.0 (53.5–355.8) | 817.5 (348.5–3031.0) | 92.5 (42.3–266.5) | 0.000 |
< 241 | 64/100 (64%) | 1/14 (7%) | 63/86 (73%) | 0.000 | |
≥241 | 36/100 (36%) | 13/14 (93%) | 23/86 (27%) | .. | |
Albumin, g/L | 35–52 | 34.8 (31.7–39.5) | 31.5 (28.5–34.0) | 36.5 (32.5–39.8) | 0.002 |
< 35 | 52 (51%) | 13 (97%) | 39 (45%) | 0.003 | |
≥35 | 50 (49%) | 2 (13%) | 48 (55%) | .. | |
Alanine aminotransferase, U/L | ≤41 | 23.0 (14.0–34.3) | 17.0 (13.0–29.0) | 23.0 (14.0–35.0) | 0.223 |
≤41 | 86 (84%) | 14 (93%) | 72 (83%) | 0.298 | |
> 41 | 16 (16%) | 1 (7%) | 15 (17%) | .. | |
Aspartate aminotransferase, U/L | ≤40 | 26.0 (19.0–41.8) | 34.0 (24.0–54.0) | 25.0 (19.0–38.0) | 0.187 |
≤40 | 75 (74%) | 9 (80%) | 66 (76%) | 0.198 | |
> 40 | 27 (26%) | 6 (20%) | 21 (24%) | .. | |
Total bilirubin, μmol/L | ≤26 | 8.5 (6.6–11.6) | 8.4 (6.6–15.3) | 8.5 (6.6–11.4) | 0.752 |
Creatinine, μmol/L | 59–104 | 68.0 (59.5–84.3) | 94.0 (63.0–164.0) | 67.0 (58.0–84.0) | 0.014 |
≤104 | 89 (87%) | 9 (60%) | 80 (92%) | 0.001 | |
> 104 | 13 (13%) | 6 (40%) | 7 (8%) | .. | |
Blood urea nitrogen, mmol/L | 3.6–9.5 | 4.6 (3.2–6.2) | 9.2 (5.4–13.7) | 4.3 (3.2–5.5) | 0.000 |
≤9.5 | 91 (89%) | 8 (53%) | 83 (96%) | 0.000 | |
> 9.5 | 11 (11%) | 7 (47%) | 4 (4%) | .. | |
Potassium, mmol/L | 3.50–5.10 | 4.2 (3.8–4.5) | 4.4 (3.6–5.1) | 4.1 (3.8–4.5) | 0.171 |
< 3.5 | 13 (13%) | 2 (13%) | 11 (13%) | 0.012 | |
3.5–5.1 | 81 (79%) | 9 (60%) | 72 (83%) | .. | |
> 5.1 | 8 (8%) | 4 (27%) | 4 (4%) | .. | |
Sodium, mmol/L | 136–145 | 137.7 (135.8–141.1) | 138.6 (133.9–142.6) | 137.6 (136.0–141.1) | 0.970 |
< 136 | 26 (25%) | 5 (33%) | 21 (24%) | 0.248 | |
136–145 | 74 (73%) | 9 (60%) | 65 (75%) | .. | |
> 145 | 2 (2%) | 1 (7%) | 1 (1%) | .. | |
Calcium, mmol/L | 2.20–2.55 | 2.1 (2.0–2.2) | 2.0 (1.9–2.2) | 2.1 (2.1–2.3) | 0.004 |
< 2.2 | 70 (69%) | 14 (93%) | 56 (64%) | 0.026 | |
≥2.2 | 32 (31%) | 1 (7%) | 31 (36%) | .. | |
Procalcitonin, ng/mL | < 0.05 | 0.06 (0.03–0.15) | 0.19 (0.12–0.60) | 0.05 (0.03–0.10) | 0.000 |
< 0·05 | 40 (39%) | 0 (0%) | 40 (46%) | 0.000 | |
≥0·05 | 62 (61%) | 15 (100%) | 47 (54%) | .. | |
High-sensitivity C-reactive Protein (hs-CRP), mg/L | < 1 | 34.0 (5.8–86.6) | 78.7 (51.3–166.3) | 25.4 (3.9–81.3) | 0.003 |
< 3 | 16 (16%) | 0 (0%) | 16 (18%) | 0.119 | |
≥3 | 86 (84%) | 15 (100%) | 71 (82%) | .. | |
IL-1β, pg/ml | < 5 | 4.9 (4.0–4.9) | 4.5 (4.0–4.9) | 4.9 (4.0–4.9) | 0.388 |
IL-2R, U/ml | 223–710 | 605.5 (380.8–896.8) | 1166.5 (898.8–1788.5) | 571.5 (353.0–821.8) | 0.001 |
IL-6, pg/ml | < 7 | 4.7 (2.2–20.3) | 48.4 (12.6–154.1) | 4.2 (1.9–16.4) | 0.000 |
IL-8, pg/ml | < 62 | 10.2 (6.7–19.9) | 22.0 (14.0–28.4) | 9.3 (6.4–18.6) | 0.006 |
IL-10, pg/ml | < 9.1 | 4.9 (4.0–4.9) | 4.9 (4.0–10.0) | 4.9 (4.0–4.9) | 0.601 |
TNF-α, pg/ml | < 8.1 | 7.5 (5.6–10.1) | 13.0 (8.3–23.3) | 7.3 (5.6–9.4) | 0.006 |