Fig. 8From: Caffeine prevents hyperoxia-induced lung injury in neonatal mice through NLRP3 inflammasome and NF-κB pathwayPotential mechanisms of the caffeine treatment-mediated mitigation of hyperoxia-induced lung injury in neonatal mice. High oxygen exposure led to the release of reactive oxygen species (ROS) in newborn mice lung, activated the NF-κB pathway and NLRP3 inflammasomes release, resulted in lung cell damage and alveolar simplification. Caffeine could antagonize A2AR and inhibit the NF-κB pathway, reduce the activation of NLRP3 inflammasome, and alleviate the alveolar injuryBack to article page