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Fig. 5 | Respiratory Research

Fig. 5

From: Caffeine prevents hyperoxia-induced lung injury in neonatal mice through NLRP3 inflammasome and NF-κB pathway

Fig. 5

The effect of caffeine on SFTPC expression and apoptosis. After 14 days of high oxygen exposure, SFTPC protein expression was significantly decreased, and the number of apoptotic cells was increased. Caffeine treatment reversed these effects. a Representative SFTPC-positive cells in the lungs of each group as determined by IF staining (microscopy, × 200). Scale bars = 100 μm. b The protein level of SFTPC in lung as determined by western blotting. c Representative images and an analysis of TUNEL staining (microscopy, × 200). Scale bars = 100 μm. The values are the mean ± SD; n = 8 fields/group. **P < 0.01 Hyperoxia (HO) group versus Normoxia (NO) group, ##P < 0.01 Hyperoxia + Caffeine (HC) group versus HO group, ▲P < 0.05 NO group versus HC group,ΨΨP < 0.01 NO group versus HC group

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Respiratory Research

ISSN: 1465-993X

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