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Table 2 Pathways related to neutrophil migration predicted to be differentially activated by proteins in T2- and T17-EVs

From: T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles

 

T17-EVs

T2-EVs

Pathway

Activation z-score

Implicated proteins

Activation z-score

Implicated proteins

Migration of neutrophils

1.929

AKT2, CD47, FN1, SAA1, TNFRSF1A

  

Quantity of neutrophils

1.504

CD47, CSF3, GNAI2, LYN, PRKCD, SLPI, TNFAIP3, TNFRSF1A

  

Cell movement of neutrophils

1.367

AKT2, CD47, CFB, CSF3, FN1, GNAI2, LYN, PIGR, PLTP, SAA1, TNFAIP3, TNFRSF1A, TNIP1

−0.287

BST1, CD36, CD44, GSN, NOS2, PLCB3, PLTP

Infiltration by neutrophils

0.468

CFB, CSF3, PLTP, TNFAIP3, TNFRSF1A, TNIP1

−1.77

CD36, CD44, NOS2, PLCB3, PLTP

Immune response of neutrophils

−0.134

CD47, CSF3, FN1, LYN, SAA1

  

Adhesion of neutrophils

  

−0.655

CD44, NOS2, PLCB3, PLTP

  1. This table contains all pathways containing the term “neutrophil” that were given an activation z-score using Ingenuity Pathway Analysis on the EV proteomics. Activation z-score > 0 suggests activated pathway, Activation z-score < 0 suggests inhibited pathway. See data for implicated proteins in Fig. 6.