Table 1 Common EV proteins detected in the epithelial EV proteome
Protein group | Proteins |
|---|---|
Rabs | Rab-1A, −1B, −2A, −3D, −4A, −5A, −5B, −5C, −6A, −7A, −8A |
Rab-10, −11A, − 13, − 14, − 18 | |
Rab-20, − 21, − 23, − 25, −27A, −27B | |
Rab-34, − 35 | |
Annexins | Annexin A1, A2, A3, A4, A5, A6, A7, A11 |
Tetraspanins | CD9, CD63, CD81, CD82, CD151, TSPAN6, TSPAN8, TSPAN14 |
Common EV markers | MHC class I, MHC class II, Ezrin, Flotillin-1, Flotillin-2, Cofilin-1, Profilin-1, CD59, 14–3-3 protein (beta/alpha, epsilon, eta, gamma, sigma, theta, zeta/delta), |
Heat shock proteins | HSPA1A, HSPA4, HSPA8, HSPH1, HSPB1, HSP90AA1, HSP90AB1 |
ESCRT | ESCRT-0 – HGS |
ESCRT-I – VPS-28, VPS-37B, VPS-37C, TSG101, MVB-12A | |
ESCRT-II – VPS-36 | |
ESCRT-III – CHMP1A, CHMP1B, CHMP2A, CHMP2B, CHMP4A, CHMP4B, CHMP5, CHMP6, IST1 | |
ESCRT accessory – VPS-4A, VPS-4B, VTA1, Clathrin, Alix |