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Table 3 Bayesian Analysis of Change from Baseline SGRQ Score up to Month 6

From: CXCR2 antagonist for patients with chronic obstructive pulmonary disease with chronic mucus hypersecretion: a phase 2b trial

 

Placebo

DNX 5 mg

DNX 10 mg

DNX 25 mg

DNX 35 mg

DNX 50 mg

N

101

102

100

103

100

99

Baseline SGRQ Total Score

46.21 (17.426)

47.16 (16.057)

45.97 (14.991)

48.47 (17.514)

47.18 (15.871)

46.19 (16.669)

n

85

96

86

90

86

85

Mean Change from Baseline (90% CI)

−4.11 (−6.25,-2.00)

−3.44 (−5.51,-1.38)

−4.19 (−6.28,-2.12)

−4.94 (−7.03,-2.91)

−4.12 (−6.22,-1.99)

−3.41 (−5.55,-1.26)

Mean Difference from Placebo (90% CI)

 

0.68 (−2.26,3.67)

−0.08 (− 3.05,2.84)

−0.83 (− 3.81,2.09)

−0.01 (− 3.06,2.97)

0.70 (−2.33,3.76)

  1. N Number enrolled, n Number of subjects with analysable data at the current time point; CI Credible interval