Number of participants, N (%) | ||||||
---|---|---|---|---|---|---|
Placebo(N = 102) | DNX 5 mg (N = 102) | DNX 10 mg (N = 103) | DNX 25 mg (N = 103) | DNX 35 mg (N = 102) | DNX 50 mg (N = 102) | |
Current smoker | 39 (38) | 40 (39) | 37 (36) | 35 (34) | 38 (37) | 36 (35) |
Former smoker | 63 (62) | 62 (61) | 66 (64) | 68 (66) | 64 (63) | 66 (65) |
SGRQ | ||||||
Q1 (I cough) most days a week or several days a week | 80 (79) | 86 (85) | 74 (73) | 80 (78) | 78 (76) | 82 (81) |
Q2 (I bring up phlegm) most days a week or several days a week | 82 (81) | 80 (79) | 65 (64) | 81 (79) | 77 (75) | 80 (79) |
Chronic mucus hypersecretion (CMH)a | ||||||
CMH+ | 75 (74) | 76 (75) | 58 (57) | 75 (74) | 68 (67) | 73 (72) |
CMH- | 26 (26) | 25 (25) | 43 (43) | 27 (26) | 34 (33) | 28 (28) |
E-RS: COPD total score | ||||||
< 10 | 37 (36) | 35 (34) | 42 (41) | 44 (43) | 37 (36) | 45 (44) |
≥ 10 | 65 (64) | 67 (66) | 60 (59) | 59 (57) | 65 (64) | 57 (56) |
CAT score | ||||||
< 10 | 13 (13) | 11 (11) | 14 (14) | 14 (14) | 8 (8) | 9 (9) |
≥ 10 | 88 (87) | 90 (89) | 87 (86) | 85 (86) | 93 (92) | 91 (91) |
Exacerbation history: | ||||||
Moderate/severe | ||||||
1 | 15 (15) | 19 (19) | 26 (25) | 17 (17) | 11 (11) | 22 (22) |
≥ 2 | 87 (85) | 83 (81) | 76 (74) | 86 (83) | 91 (89) | 80 (78) |
Medications | ||||||
ICS + LABA + LAMA | 39 (38) | 44 (43) | 45 (44) | 43 (42) | 39 (38) | 40 (39) |
LABA + LAMA | 24 (24) | 23 (23) | 30 (29) | 20 (19) | 21 (21) | 34 (33) |
ICS + LABA | 19 (19) | 20 (20) | 19 (18) | 27 (26) | 25 (25) | 15 (15) |
LAMA | 11 (11) | 7 (7) | 4 (4) | 8 (8) | 10 (10) | 5 (5) |
Inflammatory markers | ||||||
CRP (mg/L) | 5.6 (9.4) | 7.2 (23.8) | 7.1 (15.1) | 8.0 (17.5) | 4.3 (5.0) | 5.5 (8.1) |
Fibrinogen (g/L) | 3.3 (0.9) | 3.4 (1.0) | 3.4 (0.9) | 3.4 (0.8) | 3.3 (0.8) | 3.4 (0.8) |