Special interest group/subgroup | FF/UMEC/VI (N = 4151) | FF/VI (N = 4134) | UMEC/VI (N = 2070) | |||
---|---|---|---|---|---|---|
Total duration at risk (patient-years) | 3714.9 | 3457.9 | 1698.3 | |||
 | n (%) | Rate [#] | n (%) | Rate [#] | n (%) | Rate [#] |
CVAESIa | 450 (11) | 167.2 [621] | 430 (10) | 157.0 [543] | 224 (11) | 166.6 [283] |
 Cardiac arrhythmia | 153 (4) | 50.9 [189] | 161 (4) | 51.5 [178] | 81 (4) | 51.2 [87] |
  Arrhythmia-related investigations, signs and symptoms (SMQ) | 63 (2) | 19.7 [73] | 71 (2) | 22.8 [79] | 33 (2) | 20.6 [35] |
  Bradyarrhythmia terms, nonspecific (SMQ) | 0 (0) | 0 [0] | 0 (0) | 0 [0] | 0 (0) | 0 [0] |
  Cardiac arrhythmia terms, nonspecific (SMQ) | 7 (< 1) | 1.9 [7] | 10 (< 1) | 2.9 [10] | 6 (< 1) | 3.5 [6] |
  Conduction defects (SMQ) | 20 (< 1) | 5.7 [21] | 16 (< 1) | 4.6 [16] | 10 (< 1) | 5.9 [10] |
  Disorders of sinus node function (SMQ) | 3 (< 1) | 0.8 [3] | 2 (< 1) | 0.6 [2] | 0 (0) | 0 [0] |
  Supraventricular tachyarrhythmias (SMQ) | 65 (2) | 18.8 [70] | 51 (1) | 15.9 [55] | 27 (1) | 16.5 [28] |
  Tachyarrhythmia terms, nonspecific (SMQ) | 3 (< 1) | 0.8 [3] | 4 (< 1) | 1.2 [4] | 1 (< 1) | 0.6 [1] |
  Ventricular tachyarrhythmias (SMQ) | 13 (< 1) | 3.5 [13] | 13 (< 1) | 3.8 [13] | 7 (< 1) | 4.1 [7] |
 Cardiac failure (SMQ) | 138 (3) | 42.5 [158] | 126 (3) | 42.8 [148] | 68 (3) | 44.8 [76] |
 CNS hemorrhages and cerebrovascular conditions (SMQ) | 41 (< 1) | 12.1 [45] | 28 (< 1) | 9.3 [32] | 11 (< 1) | 6.5 [11] |
 Hypertension (SMQ) | 113 (3) | 35.5 [132] | 115 (3) | 35.0 [121] | 54 (3) | 34.2 [58] |
 Ischemic heart disease (SMQ) | 80 (2) | 26.1 [97] | 57 (1) | 18.5 [64] | 47 (2) | 30.6 [52] |