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Fig. 7 | Respiratory Research

Fig. 7

From: Influence of gender in monocrotaline and chronic hypoxia induced pulmonary hypertension in obese rats and mice

Fig. 7

Effects of obesity on hemodynamics, right ventricular hypertrophy and function, and pulmonary vascular remodeling in chronic hypoxia (HOX)-induced pulmonary hypertension (PH) in female B6 mice. Hemodynamics and right ventricular hypertrophy measurements were performed after 5 weeks of either normoxic (NOX) (WT NOX (n = 10); OB NOX (n = 9–10)) or hypoxic (HOX) (WT HOX (n = 10); OB HOX (n = 8–10)) exposure in wild type (WT) lean and obese (OB) female B6 mice. a Body mass index (BMI) and (b-e) different hemodynamic and right ventricular hypertrophy/function parameters are given. f Degree of muscularization (fully muscularized pulmonary vessels) is shown. SAP = systemic arterial pressure, RVSP = right ventricular systolic pressure, RV = right ventricle, LV + S = left ventricle plus septum, TAPSE = tricuspid annular plane systolic excursion. Data are presented as mean ± SEM (n = 8–10). p < 0.05 values are considered statistically significant. *compared to wild type, $compared to normoxia

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