Fig. 6

Effects of obesity on hemodynamics, right ventricular hypertrophy and function, and pulmonary vascular remodeling in chronic hypoxia (HOX)-induced pulmonary hypertension (PH) in male B6 mice. Hemodynamics and right ventricular hypertrophy measurements were performed after 5 weeks of either normoxic (NOX) (WT NOX (n = 5–10); OB NOX (n = 5–20)) or hypoxic (HOX) (WT HOX (n = 5–10); OB HOX (n = 5–20)) exposure in wild type (WT) lean and obese (OB) male B6 mice. a Body mass index (BMI) and (b-e) different hemodynamic and right ventricular hypertrophy/function parameters are given. f Degree of muscularization (fully muscularized pulmonary vessels) is shown. SAP = systemic arterial pressure, RVSP = right ventricular systolic pressure, RV = right ventricle, LV + S = left ventricle plus septum, TAPSE = tricuspid annular plane systolic excursion. Data are presented as mean ± SEM (n = 5–20). p < 0.05 values are considered statistically significant. *compared to wild type, ^$compared to normoxia