Skip to main content
Fig. 2 | Respiratory Research

Fig. 2

From: Influence of gender in monocrotaline and chronic hypoxia induced pulmonary hypertension in obese rats and mice

Fig. 2

Effects of obesity on hemodynamics, right ventricular hypertrophy and pulmonary vascular remodeling in monocrotaline (MCT)-induced pulmonary hypertension (PH) in male Zucker rats. Hemodynamics and right ventricular hypertrophy measurements were performed after 5 weeks of either normal saline (NS) (NS Lean (n = 9–10); NS Obese (n = 9–10)) or monocrotaline (MCT Lean (n = 6–11); MCT Obese (n = 2–11)) treatment in lean and obese male Zucker rats. a, b Hemodynamic measurements and (c) Fulton’s index (weight ratio of right ventricle (RV) to left ventricle and septum (LV + S)) are shown. d-e Medial wall thickness and degree of muscularization are given. f Representative photomicrographs of medial wall thickness for different groups are depicted. Pulmonary vessels are indicated by arrows. SAP = systemic arterial pressure, RVSP = right ventricular systolic pressure. Data are presented as mean ± SEM (n = 2–11). p < 0.05 values are considered statistically significant. $compared to normal saline

Back to article page