Characteristics | Complete dataset (n = 142) | PAH (n = 90) | PAH with comorbidities (n = 52) | p-value between groups | |||
---|---|---|---|---|---|---|---|
Mean ± SD or n (%) | n | Mean ± SD or n (%) | n | Mean ± SD or n (%) | n | ||
Age [years] | 63.3 ± 14.7 |  | 59.0 ± 15.7 |  | 70.8 ± 8.7 |  | < 0.0001 |
Vital signs | |||||||
 Heart rate [/min] | 79 ± 14 |  | 79 ± 13 |  | 78 ± 12 |  | 0.70 |
 Oxygen saturation SaO2 [%] | 94.7 ± 2.7 | 106 | 95.6 ± 2.4 | 62 | 93.6 ± 3.3 | 44 | 0.001 |
WHO-FC no. [%] | Â | Â | Â | Â | Â | Â | 0.021 |
 II | 25 (20.2%) |  | 22 (29.0%) |  | 3 (6.3%) |  |  |
 III | 84 (67.7%) |  | 48 (63.2%) |  | 36 (75.0%) |  |  |
 IV | 15 (12.1%) |  | 6 (7.8%) |  | 9 (18.7%) |  |  |
Laboratory | |||||||
 NT-proBNP [ng/l] | 2334 ± 3270 | 104 | 2063 ± 3427 | 65 | 2786 ± 2976 | 39 | 0.26 |
 Creatinine [mg/dl] | 1.04 ± 0.42 | 141 | 0.93 ± 0.39 | 89 | 1.24 ± 0.4 | 52 | < 0.0001 |
 GFR [ml/min/1.73m2] | 69.52 ± 24.99 | 136 | 77.41 ± 24.96 | 86 | 55.95 ± 18.52 | 50 | < 0.0001 |
 Ferritin [μg/l] | 194.8 ± 188.5 | 77 | 177.7 ± 151 | 47 | 221.4 ± 236.1 | 30 | 0.33 |
6MWT | |||||||
 6MWD [m] | 332.6 ± 127.7 | 111 | 372.6 ± 115.5 | 67 | 271.8 ± 122.3 | 44 | < 0.0001 |
Lung function tests | |||||||
 DLCOsb [%] | 48.4 ± 21.8 | 124 | 53.5 ± 21.7 | 77 | 40.0 ± 19.4 | 47 | 0.001 |
 TLC [%] | 90.5 ± 20.5 | 136 | 90.2 ± 21.1 | 85 | 90.9 ± 19.7 | 51 | 0.85 |
 FEV1 [%] | 83.9 ± 23.2 | 138 | 83.2 ± 26.0 | 86 | 85.0 ± 17.7 |  | 0.62 |
Right heart catheterization at rest | |||||||
 RAP [mmHg] | 7.9 ± 4.8 | 104 | 7.1 ± 4.4 | 63 | 9.2 ± 5.2 | 41 | 0.033 |
 mPAP [mmHg] | 43.2 ± 11.7 |  | 43.1 ± 12.0 |  | 43.4 ± 11.2 |  | 0.88 |
 Cardiac output [l/min] | 4.6 ± 1.2 | 126 | 4.6 ± 1.3 | 79 | 4.4 ± 1.1 | 47 | 0.36 |
 Cardiac index [l/min/m2] | 2.4 ± 0.6 | 117 | 2.5 ± 0.6 | 72 | 2.3 ± 0.5 | 44 | 0.035 |
 PAWP [mmHg] | 9.6 ± 3.1 | 136 | 9.3 ± 3.2 | 84 | 10.2 ± 2.9 |  | 0.084 |
 PVR [dyn*s*cm−5] | 648 ± 326 | 135 | 655 ± 351 | 84 | 635 ± 284 | 51 | 0.71 |
 SvO2 [%] | 65.5 ± 8.6 | 95 | 66.0 ± 9.3 | 58 | 62.0 ± 6.8 | 37 | 0.020 |
Echocardiography | |||||||
 RA [cm2] | 20.4 ± 6.3 | 136 | 19.2 ± 6.3 | 85 | 22.4 ± 5.9 | 51 | 0.003 |
 RV [cm2] | 24.2 ± 7.0 | 138 | 23.5 ± 7.2 | 87 | 25.4 ± 6.6 | 51 | 0.13 |
 sPAP [mmHg] | 63.5 ± 19.5 | 140 | 62.6 ± 20.11 | 88 | 65.2 ± 18.4 | 52 | 0.43 |
 TAPSE [cm] | 1.9 ± 0.5 | 139 | 1.97 ± 0.53 | 88 | 1.90 ± 0.56 | 51 | 0.47 |
 LV-EI | 1.28 ± 0.25 | 113 | 1.3 ± 0.2 | 74 | 1.3 ± 0.3 | 39 | 0.85 |
RV pump function no. [%] | |||||||
 normal | 22 (15.8%) |  | 19 (21.8%) |  | 3 (5.9%) |  |  |
 mild impairment | 15 (10.8%) |  | 7 (8.0%) |  | 8 (15.7%) |  |  |
 moderate impairment | 28 (20.1%) |  | 15 (17.2%) |  | 13 (25.5%) |  |  |
 severe impairment | 74 (53.3%) |  | 46 (53.0%) |  | 28 (52.9%) |  |  |