Skip to main content
Fig. 4 | Respiratory Research

Fig. 4

From: Characterisation of microbiota in saliva, bronchoalveolar lavage fluid, non-malignant, peritumoural and tumour tissue in non-small cell lung cancer patients: a cross-sectional clinical trial

Fig. 4

Diversity and predominant taxa in lung samples from upper and lower tumour lobes. Beta diversity found significantly different between peritumoural tissue from upper and lower lobes based on both a weighted (wUF) and b unweighted (uwUF) UniFrac distances. c Significantly different beta diversity based on wUF between peritumoural tissue and tumour in the upper lobe. d Weighted and e unweighted UF distances between samples coming from the same patient (i.e. paired distances) compared between upper and lower tumour lobes. The facet name represents the referent sample (e.g. “distance to BAL”) to which were calculated the distances noted on x-axis (e.g. “from LUNG.T”). Smaller distance indicates increased similarity. Alpha diversity for four lung samples between upper and lower tumour lobe assessed by f Faith’s phylogenetic diversity, g number of observed OTUs, and h Shannon diversity. i Most abundant phyla in each of the microbiota samples if the tumour is found in upper or lower lobes. Significance of difference in beta diversity was assessed with adonis function (vegan, 999 permutations). Statistical significance in alpha diversity and paired distances was assessed with Kruskal-Wallis followed by, where appropriate, Man-Whitney U test with BH correction for multiple comparison. *: p ≤ 0.05, **: p ≤ 0.01. BAL - bronchoalveolar lavage fluid, LUNG.DP - non-malignant distal piece, LUNG.PT - peritumoural tissue, LUNG. T - tumour

Back to article page