Fig. 1

NF-κB aggravates LPS-induced ALI. Mice were treated with PDTC or DMSO in the presence of LPS. a Pathological changes of lung tissues in mice by HE staining (200×); b W/D ratio of lung tissue in mice; c Activity of NF-κB in mice measured by ELISA and western blot analysis; d Total cells, macrophages, lymphocytes and neutrophils in BALF of mice; e Activity of MPO in different groups of mice. Measurement data were presented as mean ± standard deviation, and data between different groups were compared by unpaired t-test (n = 12 per group). *, p < 0.05