Table 4 Pearson’s correlation value (r) and significance values (p) depicting the extent to which the 13 dysregulated immunological mediators (significantly altered in ACO vs. asthma, ACO vs. COPD and ACO vs controls) are linearly related to FEV1 and FEV1/FVC of ACO subjects
From: Metabolomic fingerprinting and systemic inflammatory profiling of asthma COPD overlap (ACO)
Marker | Correlation | |||
|---|---|---|---|---|
ACO vs FEV1 | ACO vs FEV1/FVC | |||
Pearson (r) | p-value | Pearson (r) | p-value | |
TNFα | −0.3717 | 0.0279 | −0.2744 | ns |
IL-1β | −0.4362 | 0.0088 | −0.6578 | < 0.0001 |
IL-17E | −0.04455 | ns | −0.3067 | ns |
GM-CSF | −0.09277 | ns | −0.3762 | 0.0259 |
IL-18 | −0.3219 | ns | −0.1835 | ns |
NGAL | −0.3559 | 0.0359 | −0.3947 | 0.0190 |
IL-5 | −0.3519 | 0.0382 | −0.6168 | < 0.0001 |
IL-10 | 0.1457 | ns | 0.1785 | ns |
MCP-1 | −0.1067 | ns | −0.2734 | ns |
YKL-40 | −0.4665 | 0.0047 | −0.7473 | < 0.0001 |
IFN-γ | −0.5192 | 0.0014 | −0.6352 | < 0.0001 |
IL-6 | −0.476 | 0.0038 | −0.6342 | < 0.0001 |
TGF-β | −0.2106 | 0.2247 | 0.0011 | ns |