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Fig. 2 | Respiratory Research

Fig. 2

From: Cisplatin treatment induced interleukin 6 and 8 production alters lung adenocarcinoma cell migration in an oncogenic mutation dependent manner

Fig. 2

A549 and PC-9 cell viability and migration alteration post cisplatin and erlotinib treatment. a 200 μm light microscopy images of 3D lung model of NHLF-A549 (75–25%) co-culture b 200 μm light microscopy images of 3D lung model of NHLF-PC-9 (75–25%) co-culture. c Percentage of cell viability expectancy for A549 and PC-9 versus erlotinib concentrations (1, 10, 100, 1000 nM). Data are presented as individual survival points ± SEM. d Summary of the NanoShuttle magnetic beads migration assay protocol. e A549 and PC-9 migration capacity at different time points (0, 6, 12, 24 h) following cisplatin (30 nM) and erlotinib (100 nM) treatment. f Quantification of migration capacity using gap area measurement. Data are presented as % of Gap area compared to 0 h ± SEM and significant changes are marked as (P < 0.05) and (P < 0.001)

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