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Table 2 Risk of long-term adverse outcomes by CID status in TORCH and ECLIPSE [48]

From: Measuring disease activity in COPD: is clinically important deterioration the answer?

Outcome

TORCH (n = 5292)

ECLIPSE (n = 1953)

CID+ at 6 months [N = 2870],

n (%)

CID- at 6 months [N = 2422],

n (%)

% risk increase assessed at 7–36 months

(95% CI)

CID+ at 12 months [N = 1442],

n (%)

CID- at 12 months [N = 531],

n (%)

% risk increase assessed at 13–36 months

(95% CI)

Moderate/severe exacerbation

2082 (73)

1450 (60)

61 (50, 72)

1082 (75)

232 (44)

154 (120, 193)

Hospital admission for severe exacerbations

797 (28)

491 (20)

55 (38, 73)

454 (31)

66 (12)

181 (117, 263)

All-cause mortality

237 (8)

160 (7)

41 (15, 72)

121 (8)

27 (5)

59 (4, 141)

  1. CID was defined as: FEV1, deterioration ≥ 100 mL or SGRQ deterioration ≥ 4 units or a first moderate/severe exacerbation on any treatment in both trials. All comparisons are for CID+ versus CID- cohorts. p < 0.05 for all risk increases in both trials
  2. CI confidence interval, CID clinically important deterioration; CID+ cohort with a short-term deterioration (i.e. early unstable cohort); CID- cohort without a short-term deterioration (i.e. early stable cohort)